Omega-3 fatty acids reduce the development of preneoplasic lesions

Autores/as

  • Viviana Teixeira HENRIQUES Universidade Federal de Viçosa
  • Cristina Maria Ganns Chaves DIAS Universidade Federal do Tocantins
  • Sylvia do Carmo Castro FRANCESCHINI Universidade Federal de Viçosa
  • Céphora Maria SABARENSE Universidade Federal de Viçosa
  • Neuza Maria Brunoro COSTA Universidade Federal de Viçosa
  • Jacqueline Isaura Alvarez LEITE Universidade Federal de Minas Gerais
  • Maria do Carmo Gouveia PELUZIO Universidade Federal de Viçosa

Palabras clave:

Fatty acids, Precancerous, Dietary supplements

Resumen

Objective
The purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats.

Methods
A total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography.

Results
The omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28.

Conclusion
These results suggest that omega-3 may slow the progress of colorectal carcinogenesis.

Citas

Waitzberg DL, editor. Nutrição oral, enteral e parenteral na prática clínica. São Paulo: Atheneu; 2000.

Teitelbaum JA, Allan Walker W. Review: the role of omega 3 fatty acids in intestinal inflammation. J Nutr Biochem. 2001; 12(1):21-32.

Tapiero H, Ba GN, Couvreur P, Tew KD. Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. Biomed Pharmacother. 2002; 56(5):215-22.

Calder PC. Polyunsaturated fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids. 2006; 75(3):197-202.

Chapkin RS, McMurray DN, Lupton JR. Colon cancer, fatty acids and anti-inflammatory compounds. Curr Opin Gastroenterol. 2007; 23(1):48-54.

Esteve J, Kricker A, Parkin DM, editors. Facts and figures of colon cancer in the European community. Lyon: International Agency for Research on Câncer; 1993.

Llor X, Pons E, Roca A, Alvarez M, Mañé J, Fernández-Bañares F, et al. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clin Nutr. 2003; 22(1):71-9.

Roynette CE, Calder PC, Dupertuis YM, Pichard C. n-3 Polyunsaturated fatty acids and colon cancer prevention. Clin Nutr. 2004; 23(2):139-51.

Reddy BS. Omega-3 fatty acids in colorectal cancer prevention. Int J Cancer. 2004; 112(1):1-7.

Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A. Dietary long chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr. 2004; 79(6):935-45.

Rodrigues MAM, Silva LAG, Salvadori DMF, De Camargo JLV, Montenegro MR. Aberrant crypt foci and colon cancer: comparison between a short-and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats. Braz J Med Biol Res. 2002; 35(3):351-5.

Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 Purified diets of laboratory rodents final report of the American Institute Nutrition ad hoc writing committee on there formulation of the AIN-76A rodent diet. J Nutr. 1993; 123(11):1939-51.

Bird RP. Observations and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Letter.1987; 37(2):147-51.

Folch J, Lees M, Sloane SG. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957; 226(1):497-509.

Hartman L, Lago RC. Rapid preparation of fatty acid methyl esters from lipids. Lab Pratic. 1973; 22(6):475-6.

Good CK, Lasko CM, Adam J, Bird PR. Diverse effects of fish oil on the growth of aberrant crypt foci and tumor multiplicity in F344 rats. Nutr Cancer. 1998; 31(3):204-11.

Bird RP. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett. 1995; 93 (1):55-71.

Courtiney ED, Matthews S, Finlayson C, Di Pierro D, Belluzzi A, Roda E, et al. Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas. Int J Colorectal Dis. 2007; 22(7):775-6.

Chapkina RS. Mechanisms by which docosahexaenoic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestine. Chem Phys Lipids. 2008; 153(1):14-23.

Roynettea CE, Calderb PC, Dupertuisa, YM, Pichard C. n-3 Polyunsaturated fatty acids and colon cancer prevention. Clin Nutr. 2004; 23(2):139-51.

Descargas

Publicado

2023-08-30

Cómo citar

Teixeira HENRIQUES, V. ., Ganns Chaves DIAS, C. M., Castro FRANCESCHINI, S. do C., SABARENSE, C. M., Brunoro COSTA, N. M., Alvarez LEITE, J. I., & Gouveia PELUZIO, M. do C. (2023). Omega-3 fatty acids reduce the development of preneoplasic lesions. Revista De Nutrição, 22(2). Recuperado a partir de https://seer.sis.puc-campinas.edu.br/nutricao/article/view/9475

Número

Vol. 22 Núm. 2 (2009): Revista de Nutrição

Sección

ARTIGOS ORIGINAIS

Licencia

Derechos de autor 2023 Viviana Teixeira HENRIQUES, Cristina Maria Ganns Chaves DIAS, Sylvia do Carmo Castro FRANCESCHINI, Céphora Maria SABARENSE, Neuza Maria Brunoro COSTA, Jacqueline Isaura Alvarez LEITE, Maria do Carmo Gouveia PELUZIO

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.