Omega-3 fatty acids reduce the development of preneoplasic lesions

Authors

  • Viviana Teixeira HENRIQUES Universidade Federal de Viçosa
  • Cristina Maria Ganns Chaves DIAS Universidade Federal do Tocantins
  • Sylvia do Carmo Castro FRANCESCHINI Universidade Federal de Viçosa
  • Céphora Maria SABARENSE Universidade Federal de Viçosa
  • Neuza Maria Brunoro COSTA Universidade Federal de Viçosa
  • Jacqueline Isaura Alvarez LEITE Universidade Federal de Minas Gerais
  • Maria do Carmo Gouveia PELUZIO Universidade Federal de Viçosa

Keywords:

Fatty acids, Precancerous, Dietary supplements

Abstract

Objective
The purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats.

Methods
A total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography.

Results
The omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28.

Conclusion
These results suggest that omega-3 may slow the progress of colorectal carcinogenesis.

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Published

2023-08-30

How to Cite

Teixeira HENRIQUES, V. ., Ganns Chaves DIAS, C. M., Castro FRANCESCHINI, S. do C., SABARENSE, C. M., Brunoro COSTA, N. M., Alvarez LEITE, J. I., & Gouveia PELUZIO, M. do C. (2023). Omega-3 fatty acids reduce the development of preneoplasic lesions. Brazilian Journal of Nutrition, 22(2). Retrieved from https://seer.sis.puc-campinas.edu.br/nutricao/article/view/9475

Issue

Vol. 22 No. 2 (2009): Revista de Nutrição

Section

ORIGINAL ARTICLE

License

Copyright (c) 2023 Viviana Teixeira HENRIQUES, Cristina Maria Ganns Chaves DIAS, Sylvia do Carmo Castro FRANCESCHINI, Céphora Maria SABARENSE, Neuza Maria Brunoro COSTA, Jacqueline Isaura Alvarez LEITE, Maria do Carmo Gouveia PELUZIO

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This work is licensed under a Creative Commons Attribution 4.0 International License.