Carotenoids as an alternative against hypovitaminosis A

Authors

  • Carmem Lygia Burgos AMBRÓSIO Universidade Federal de Pernambuco
  • Florisbela de Arruda Camara e Siqueira CAMPOS Universidade Federal de Pernambuco
  • Zelyta Pinheiro de FARO Universidade Federal de Pernambuco

Keywords:

carotenoids, biological vailability, hypovitaminosis A

Abstract

Hypovitaminosis A causes xerophthalmia, blindness and death in thousands of children throughout the world
and constitutes one of the main nutritional problems in the populations of developing countries, including
Brazil. Although fruits and vegetables, sources of carotenoids, are widely available in Brazil, hypovitaminosis
A constitutes a serious public health problem. The lack of information available to the population about the
dietary sources of carotenoids and factors affecting their bioavailability, known in the literature as SLAMENGHI,
are possible causes associated with this contradiction. Current carotenoid conversion factors to retinol are
higher than earlier ones. This suggests a reduced effectiveness in the conversion of carotenoids into the active
form of vitamin A, questioning the role of carotenoids in combating hypovitaminosis A. The aim of this review
is to discuss the bioavailability of carotenoids and their food sources in order to better assess the possibility of
using these pigments to combat hypovitaminosis A.

References

Olson JA. Metabolism and function of vitamin A. Federation Proceedings. 1969; 28(5):1670-7.

Ramalho RA, Flores H, Saunders C. Hipovitaminose A no Brasil: um problema de saúde pública. Rev Panam Salud Publica. 2002; 12(2):117-22.

World Health Organization. Global prevalence of vitamin A deficiency (WHO/NUT/95.3). Geneva; 1995.

West CE, Castenmiller JJM. Quantification of “SLAMENGHI” factors for carotenoid bioavailability and bioconversion. Int J Vit Nutr Res. 1998; 68(6):371-7.

National Academy of Sciences. Dietary Reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington (DC); 2001.

International Vitamin A Consultative Group. Conversion factors for vitamin A and Carotenoids. ILSI Research Foundation; 2002.

National Academy of Sciences. Recommended dietary allowances. 8th ed. Washington (DC); 1974.

Kim MK, Ahn SH, Lee-Kim YC. Relationship of serum α-tocopherol, carotenoids and retinol with the risk of breast cancer. Nutr Res. 2001; 21: 797-809.

Ziegler RG. Vegetables, fruits, and carotenoids and the risk of cancer. Am J Clin Nutr. 1991; 53(1 Suppl):2515-95.

Olson JA. Carotenoids and human health. Arch Latinoam Nutr. 1999; 49(1-S):7-11.

Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Manson JE, Willett WC. Dietary carotenoids and risk of coronary artery disease in women. Am J Clin Nutr. 2003; 77(6):1390-9.

Gale CR, Ashurst HE, Powers HJ, Martyn CN. Antioxidant vitamin status and carotid atherosclerosis in the elderly. Am J Clin Nutr. 2001; 74(3):402-8.

Landrum JT, Bone RA. Lutein, zeaxanthin, and the macular pigment. Arch Biochem Biophys. 2001; 385(1):28-40.

Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidants vitamins. Am J Clin Nutr. 1995; 62(6 Suppl):1448S-61S.

Cornwell DG, Kruger FA. Studies on the absorption of beta-carotene and the distribution of total carotenoid in human serum lipoproteins after oral administration. J Lipid Research 1962; 3 (1):65-70.

Johnson EJ, Russell RM. Distribution of orally administered beta-carotene among lipoproteins in healthy men. Am J Clin Nutr. 1992; 56(1): 128-35.

Olson JA. Bioavailability of carotenoids. Arch Latinoam Nutr. 1999; 49(1-S):21-5.

Gronowska-Senger A, Wolf G. Effect of dietary protein on the enzyme from rat and human intestine which converts b-carotene to retinal. J Nutr. 1970; 100:300-8.

Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, et al. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J Biol Chem. 2001; 276 (27): 14110-16.

Gessler NN, Gomboeva SB, Shumaev KB, Bykhovskii VY, Lankin VZ. Free radical lipid peroxidation inhibits enzymatic conversion of β-carotene into vitamin A. Bull Exp Biol Med. 2001; 131(5):451-3.

Brubacher GB, Weiser H. The vitamin A activity of beta-carotene. Int J Vit Nutr Res. 1985; 55(1):5-15.

Rodriguez-Amaya DB. Carotenoids and food preparation: the retention of provitamin A carotenoids in prepared, processed, and stored foods. John Snow, Inc/OMNI Project; 1997. 88p.

Stahl W, Sies H. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr. 1992; 122(11):2161-6.

You CS, Parker RS, Goodman KJ, Swanson JE, Corso TN. Evidence of cis-trans isomerization of 9-cis-β-carotene during absorption in humans. Am J Clin Nutr. 1996; 64(2):177-83.

van Vliet T, van Vlissingen MF, van Schaik F, van Den Berg, H. β-Carotene absorption and cleavage in rats is affected by the vitamin A concentration of the diet. J Nutr. 1996; 126(2):499-508.

Borel P, Tyssandier V, Mekki N, Grolier P, Rochette Y, Alexandre-Gouabau MC, et al. Chylomicron β-carotene and retinyl palmitate responses are dramatically diminished when men ingest β-carotene with medium-chain rather than long-chain triglycerides. J Nutr. 1998; 128(8): 1361-67.

Dimitrov NV, Meyer C, Werey DE, Chenoweth W, Michelakis A, Malone W, et al. Bioavailability of beta-carotene in humans. Am J Clin Nutr. 1988; 48(2):298-304.

Tang G, Serfaty-Lacrosniere C, Camilo ME, Russell RM. Gastric acidity influences the blood response to a β-carotene dose in humans. Am J Clin Nutr. 1996; 64(4):622-6.

Brown ED, Micozzi MS, Craft NE, Bieri JG, Beecher G, Edwards BK, et al. Plasma carotenoids in normal men after a single ingestion of vegetables or purified β-carotene. Am J Clin Nutr. 1989; 49(6): 1258-65.

Micozzi MS, Brown ED, Edward BK, Bieri JG, Taylor PR, Khachik F, et al. Plasma carotenoid response to chronic intake of selected foods and β-carotene supplements in men. Am J Clin Nutr. 1992; 55(6): 1120-5.

Bulux J, Quan de Serrano V, Giuliano A, Perez R, Lopez CY, Rivera C, et al. Plasma response of children to short-term chronic β-carotene supplementation. Am J Clin Nutr. 1994; 59(6): 1369-75.

Thurmann PA, Steffen V, Zwernemann C, Acbischer CP, Cohn W, Wendt G, et al. Plasma concentration response to drinks containing beta-carotene as carrot juice or formulated as a water dispersible powder. Eur J Nutr. 2002; 41(5):228-35.

Rock CL, Swendseid ME. Plasma β-carotene response in humans after meals supplemented with dietary pectin. Am J Clin Nutr. 1992; 55(1): 96-9.

De Pee S, West CE, Permaesih D, Martuti S, Muhilal, Hautvast JG. Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and β-carotene in schoolchildren in Indonesia. Am J Clin Nutr. 1998; 68(5):1058-67.

Tang G, Gu X, Hu S, Xu Q, Quin J, Dolnikowski GG, et al. Green and yellow vegetables can maintain body stores of vitamin A in Chinese children. Am J Clin Nutr. 1999; 70(6):1069-76.

Edwards AJ, Vinyard BT, Wiley ER, Brown ED Collins JK, Perkins-Veazie P, et al. Consumption of watermelon juice increases plasma concentrations of lycopene ans β-carotene in humans. J Nutr. 2003; 133(4):1043-50.

van Kappel AL, Steghens JP, Zeleniuch-Jacquotte A, Chajes V, Toniolo P, Riboli E. Serum carotenoids as biomarkers of fruit and vegetables consumption in the New York women’s health study. Public Health Nutr. 2001; 4(3):829-35.

van Het Hof KH, Brower IA, West CE, Haddeman E, Skegers-Theunissen RP, van Dusseldop M, et al. Bioavailability of lutein from vegetables is 5 times higher than that of β-carotene. Am J Clin Nutr. 1999; 70(2):261-8.

Erdman JW Jr. Variable bioavailability of carotenoids from vegetables. Am J Clin Nutr. 1999; 70(2):179-80.

Johnson EJ, Qin J, Krinsky NI, Russell RM. Ingestion by men of a combined dose of β-carotene and lycopene does not affect the absorption of β-carotene but improves that of lycopene. J Nutr. 1997; 127(9):1833-7.

Kostic D, White WS, Olson JA. Intestinal absorption, serum clearance, and interactions between lutein and β-carotene when administered to human adults in separate or combined oral doses. Am J Clin Nutr. 1995; 62(3):604-10.

Lin Y, Dueker SR, Burri BJ, Neidlinger TR, Clifford AJ. Variability of the conversion of β-carotene to vitamin A in women measured by using a double-tracer study design. Am J Clin Nutr. 2000; 71(6):1545-54.

Bonn, D. International consortium SN(i)Ps away at individuality. Lancet. 1999; 353(9165): 1684.

Ribaya-Mercado JD, Solon FS, Solon MA, Cabal-Barza MA, Perfecto CS, Tang G, et al. Bioconversion of plant carotenoids to vitamin A in Filipino school-aged children varies inversely with vitamin A status. Am J Clin Nutr. 2000; 72(2):455-65.

Mariath JG, Lima MC, Santos LM. Vitamin A activity of buriti (Mauritia vinifera Mart) and its effectiveness in the treatment and prevention of xerophthalmia. Am J Clin Nutr. 1989; 49(5): 849-53.

Canfield LM, Kaminsky RG. Red palm oil in the maternal diet improves the vitamin A status of lactating mothers and their infants. Food Nut Bull. 2000; 21:144-8.

Mahapatra S, Manorama R. The protective effect of red palm oil in comparison with massive vitamin A dose in combating vitamin A deficiency in Orissa, Índia. Asia Pacific J Clin Nutr. 1997; 6:246-50.

Manorama R, Rukmini C. Effect of processing on β-carotene retention in crude palm oil and its products. Food Chemistry. 1991; 42(3):253-64.

Yuyama LKO, Cozzolino SMF. Efeito da suplementação com pupunha como fonte de vitamina A em dieta: estudo em ratos. Rev Saúde Pública. 1996; 30(1):61-6.

Graebner IT, Siqueira EMA, Arruda SF, Souza EMT. Carotenoids from native brazilian dark-green vegetables are bioavailable: a study in rats. Nutr Res. 2004; 24(8):671-9.

Faro ZP. Aproveitamento industrial da polpa de abóbora [tese]. Recife: Universidade Federal de Pernambuco; 2001.

Rodriguez-Amaya DB. Assessment of the provitamin A contents of foods: the brazilian experience. J Food Comp Anal. 1996; 9:196-230.

Rodriguez-Amaya DB. Latin american food sources of carotenoids. Arch Latinoam Nutr. 1999; 49(3 Suppl 1):74S-84S.

Rodriguez-Amaya DB. Some considerations in generating carotenoid data for food composition tables. J Food Comp Anal. 2000; 13:641-47.

Faber M, Phungula MAS, Venter SL, Dhansay MA, Benade AJS. Home gardens focusing on the production of yellow and dark-green leafy vegetables increase the serum retinol concentrations of 2-5-y-old children in South Africa. Am J Clin Nutr. 2002; 76(5):1048-54.

Published

2023-09-19

How to Cite

Burgos AMBRÓSIO, C. L. ., de Arruda Camara e Siqueira CAMPOS, F. ., & Pinheiro de FARO, Z. . (2023). Carotenoids as an alternative against hypovitaminosis A. Brazilian Journal of Nutrition, 19(2). Retrieved from https://seer.sis.puc-campinas.edu.br/nutricao/article/view/9784

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ARTIGOS DE REVISÃO