Carotenóides como alternativa contra a hipovitaminose A
Palabras clave:
carotenóides, disponibilidade biológica, hipovitaminose AResumen
A hipovitaminose A acarreta xeroftalmia, cegueira e morte em milhares de crianças no mundo e constitui um dos principais problemas nutricionais de populações de países em desenvolvimento, incluído o Brasil. Embora haja grande disponibilidade de frutas e verduras, fontes de carotenóides no Brasil, a hipovitaminose A constitui um grave problema de saúde pública. A falta de informação da população, no que diz respeito às fontes alimentares e aos fatores que interferem na biodisponibilidade dos carotenóides, citados na literatura, com a “mnemônica” SLAMENGHI são possíveis causas associadas a esta contradição. Os atuais fatores de conversão de carotenóides em retinol são superiores aos antigos fatores, o que pressupõe uma efetividade ainda menor na conversão dos carotenóides na forma ativa da vitamina A e coloca em questão a utilização destes no combate à hipovitaminose A. Esta revisão tem como objetivo relatar o que vem sendo abordado acerca do tema biodisponibilidade e fontes de carotenóides, para possibilitar um melhor posicionamento na utilização dos carotenóides no combate à hipovitaminose A.
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Olson JA. Metabolism and function of vitamin A. Federation Proceedings. 1969; 28(5):1670-7.
Ramalho RA, Flores H, Saunders C. Hipovitaminose A no Brasil: um problema de saúde pública. Rev Panam Salud Publica. 2002; 12(2):117-22.
World Health Organization. Global prevalence of vitamin A deficiency (WHO/NUT/95.3). Geneva; 1995.
West CE, Castenmiller JJM. Quantification of “SLAMENGHI” factors for carotenoid bioavailability and bioconversion. Int J Vit Nutr Res. 1998; 68(6):371-7.
National Academy of Sciences. Dietary Reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington (DC); 2001.
International Vitamin A Consultative Group. Conversion factors for vitamin A and Carotenoids. ILSI Research Foundation; 2002.
National Academy of Sciences. Recommended dietary allowances. 8th ed. Washington (DC); 1974.
Kim MK, Ahn SH, Lee-Kim YC. Relationship of serum α-tocopherol, carotenoids and retinol with the risk of breast cancer. Nutr Res. 2001; 21: 797-809.
Ziegler RG. Vegetables, fruits, and carotenoids and the risk of cancer. Am J Clin Nutr. 1991; 53(1 Suppl):2515-95.
Olson JA. Carotenoids and human health. Arch Latinoam Nutr. 1999; 49(1-S):7-11.
Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Manson JE, Willett WC. Dietary carotenoids and risk of coronary artery disease in women. Am J Clin Nutr. 2003; 77(6):1390-9.
Gale CR, Ashurst HE, Powers HJ, Martyn CN. Antioxidant vitamin status and carotid atherosclerosis in the elderly. Am J Clin Nutr. 2001; 74(3):402-8.
Landrum JT, Bone RA. Lutein, zeaxanthin, and the macular pigment. Arch Biochem Biophys. 2001; 385(1):28-40.
Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidants vitamins. Am J Clin Nutr. 1995; 62(6 Suppl):1448S-61S.
Cornwell DG, Kruger FA. Studies on the absorption of beta-carotene and the distribution of total carotenoid in human serum lipoproteins after oral administration. J Lipid Research 1962; 3 (1):65-70.
Johnson EJ, Russell RM. Distribution of orally administered beta-carotene among lipoproteins in healthy men. Am J Clin Nutr. 1992; 56(1): 128-35.
Olson JA. Bioavailability of carotenoids. Arch Latinoam Nutr. 1999; 49(1-S):21-5.
Gronowska-Senger A, Wolf G. Effect of dietary protein on the enzyme from rat and human intestine which converts b-carotene to retinal. J Nutr. 1970; 100:300-8.
Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, et al. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J Biol Chem. 2001; 276 (27): 14110-16.
Gessler NN, Gomboeva SB, Shumaev KB, Bykhovskii VY, Lankin VZ. Free radical lipid peroxidation inhibits enzymatic conversion of β-carotene into vitamin A. Bull Exp Biol Med. 2001; 131(5):451-3.
Brubacher GB, Weiser H. The vitamin A activity of beta-carotene. Int J Vit Nutr Res. 1985; 55(1):5-15.
Rodriguez-Amaya DB. Carotenoids and food preparation: the retention of provitamin A carotenoids in prepared, processed, and stored foods. John Snow, Inc/OMNI Project; 1997. 88p.
Stahl W, Sies H. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr. 1992; 122(11):2161-6.
You CS, Parker RS, Goodman KJ, Swanson JE, Corso TN. Evidence of cis-trans isomerization of 9-cis-β-carotene during absorption in humans. Am J Clin Nutr. 1996; 64(2):177-83.
van Vliet T, van Vlissingen MF, van Schaik F, van Den Berg, H. β-Carotene absorption and cleavage in rats is affected by the vitamin A concentration of the diet. J Nutr. 1996; 126(2):499-508.
Borel P, Tyssandier V, Mekki N, Grolier P, Rochette Y, Alexandre-Gouabau MC, et al. Chylomicron β-carotene and retinyl palmitate responses are dramatically diminished when men ingest β-carotene with medium-chain rather than long-chain triglycerides. J Nutr. 1998; 128(8): 1361-67.
Dimitrov NV, Meyer C, Werey DE, Chenoweth W, Michelakis A, Malone W, et al. Bioavailability of beta-carotene in humans. Am J Clin Nutr. 1988; 48(2):298-304.
Tang G, Serfaty-Lacrosniere C, Camilo ME, Russell RM. Gastric acidity influences the blood response to a β-carotene dose in humans. Am J Clin Nutr. 1996; 64(4):622-6.
Brown ED, Micozzi MS, Craft NE, Bieri JG, Beecher G, Edwards BK, et al. Plasma carotenoids in normal men after a single ingestion of vegetables or purified β-carotene. Am J Clin Nutr. 1989; 49(6): 1258-65.
Micozzi MS, Brown ED, Edward BK, Bieri JG, Taylor PR, Khachik F, et al. Plasma carotenoid response to chronic intake of selected foods and β-carotene supplements in men. Am J Clin Nutr. 1992; 55(6): 1120-5.
Bulux J, Quan de Serrano V, Giuliano A, Perez R, Lopez CY, Rivera C, et al. Plasma response of children to short-term chronic β-carotene supplementation. Am J Clin Nutr. 1994; 59(6): 1369-75.
Thurmann PA, Steffen V, Zwernemann C, Acbischer CP, Cohn W, Wendt G, et al. Plasma concentration response to drinks containing beta-carotene as carrot juice or formulated as a water dispersible powder. Eur J Nutr. 2002; 41(5):228-35.
Rock CL, Swendseid ME. Plasma β-carotene response in humans after meals supplemented with dietary pectin. Am J Clin Nutr. 1992; 55(1): 96-9.
De Pee S, West CE, Permaesih D, Martuti S, Muhilal, Hautvast JG. Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and β-carotene in schoolchildren in Indonesia. Am J Clin Nutr. 1998; 68(5):1058-67.
Tang G, Gu X, Hu S, Xu Q, Quin J, Dolnikowski GG, et al. Green and yellow vegetables can maintain body stores of vitamin A in Chinese children. Am J Clin Nutr. 1999; 70(6):1069-76.
Edwards AJ, Vinyard BT, Wiley ER, Brown ED Collins JK, Perkins-Veazie P, et al. Consumption of watermelon juice increases plasma concentrations of lycopene ans β-carotene in humans. J Nutr. 2003; 133(4):1043-50.
van Kappel AL, Steghens JP, Zeleniuch-Jacquotte A, Chajes V, Toniolo P, Riboli E. Serum carotenoids as biomarkers of fruit and vegetables consumption in the New York women’s health study. Public Health Nutr. 2001; 4(3):829-35.
van Het Hof KH, Brower IA, West CE, Haddeman E, Skegers-Theunissen RP, van Dusseldop M, et al. Bioavailability of lutein from vegetables is 5 times higher than that of β-carotene. Am J Clin Nutr. 1999; 70(2):261-8.
Erdman JW Jr. Variable bioavailability of carotenoids from vegetables. Am J Clin Nutr. 1999; 70(2):179-80.
Johnson EJ, Qin J, Krinsky NI, Russell RM. Ingestion by men of a combined dose of β-carotene and lycopene does not affect the absorption of β-carotene but improves that of lycopene. J Nutr. 1997; 127(9):1833-7.
Kostic D, White WS, Olson JA. Intestinal absorption, serum clearance, and interactions between lutein and β-carotene when administered to human adults in separate or combined oral doses. Am J Clin Nutr. 1995; 62(3):604-10.
Lin Y, Dueker SR, Burri BJ, Neidlinger TR, Clifford AJ. Variability of the conversion of β-carotene to vitamin A in women measured by using a double-tracer study design. Am J Clin Nutr. 2000; 71(6):1545-54.
Bonn, D. International consortium SN(i)Ps away at individuality. Lancet. 1999; 353(9165): 1684.
Ribaya-Mercado JD, Solon FS, Solon MA, Cabal-Barza MA, Perfecto CS, Tang G, et al. Bioconversion of plant carotenoids to vitamin A in Filipino school-aged children varies inversely with vitamin A status. Am J Clin Nutr. 2000; 72(2):455-65.
Mariath JG, Lima MC, Santos LM. Vitamin A activity of buriti (Mauritia vinifera Mart) and its effectiveness in the treatment and prevention of xerophthalmia. Am J Clin Nutr. 1989; 49(5): 849-53.
Canfield LM, Kaminsky RG. Red palm oil in the maternal diet improves the vitamin A status of lactating mothers and their infants. Food Nut Bull. 2000; 21:144-8.
Mahapatra S, Manorama R. The protective effect of red palm oil in comparison with massive vitamin A dose in combating vitamin A deficiency in Orissa, Índia. Asia Pacific J Clin Nutr. 1997; 6:246-50.
Manorama R, Rukmini C. Effect of processing on β-carotene retention in crude palm oil and its products. Food Chemistry. 1991; 42(3):253-64.
Yuyama LKO, Cozzolino SMF. Efeito da suplementação com pupunha como fonte de vitamina A em dieta: estudo em ratos. Rev Saúde Pública. 1996; 30(1):61-6.
Graebner IT, Siqueira EMA, Arruda SF, Souza EMT. Carotenoids from native brazilian dark-green vegetables are bioavailable: a study in rats. Nutr Res. 2004; 24(8):671-9.
Faro ZP. Aproveitamento industrial da polpa de abóbora [tese]. Recife: Universidade Federal de Pernambuco; 2001.
Rodriguez-Amaya DB. Assessment of the provitamin A contents of foods: the brazilian experience. J Food Comp Anal. 1996; 9:196-230.
Rodriguez-Amaya DB. Latin american food sources of carotenoids. Arch Latinoam Nutr. 1999; 49(3 Suppl 1):74S-84S.
Rodriguez-Amaya DB. Some considerations in generating carotenoid data for food composition tables. J Food Comp Anal. 2000; 13:641-47.
Faber M, Phungula MAS, Venter SL, Dhansay MA, Benade AJS. Home gardens focusing on the production of yellow and dark-green leafy vegetables increase the serum retinol concentrations of 2-5-y-old children in South Africa. Am J Clin Nutr. 2002; 76(5):1048-54.
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Derechos de autor 2023 Carmem Lygia Burgos AMBRÓSIO, Florisbela de Arruda Camara e Siqueira CAMPOS, Zelyta Pinheiro de FARO
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