Endotélio vascular: Parte I
função e propriedade
Palavras-chave:
endotélio vascular-tendência, homeostas, sistema vasomotor, vasoconstritores, vasodilatadoresResumo
O endotélio vascular é uma camada de células finas que reveste a superfície terminal de todos os vasos sanguíneos. Atualmente observa-se que sua função não é de simples barreira de difusão passiva entre os elementos do sangue circulante e o tecido intersticial. O endotélio intacto provê uma interface não trombogênica entre o vaso e os componentes sanguíneos, favorece a vasodilatação em diferentes condições de nuxo e estresse parietal, além de promover reparos nas áreas lesadas. Sua integridade é essencial a regulação do fluxo sanguíneo e proteção contra a trombólise. O endotélio pode ser considerado o maior órgão paracrino do organismo, que responde a vários estímulos, produzindo e secretando localmente grande número de compostos metabolicamente ativos, que atuam nas células vizinhas. O objetivo deste trabalho é expor conceitos modernos deste importante sistema orgânico.
Downloads
Referências
ALMEIDA, P.J., PIRES,J.P.G., MARQUEZINI, A.J. et al. Platelets, vessels and coagulation: basic mechanisms anc drug actions. Journal of Drug and Development, v.2, p.227-240, 1990.
BASSEGNE, F., HUCKSTOFF, C.H. Endothelium-mediated control of coronary circulation. Acta Cardiologica, Bruxelles, v.46, p.419-24, 1991.
BOES, M., DAKE, B.L., BAR, R.S. Interations of cultures endothelial cells with TGF-beta, bTGF, PDGF and IGF-I. Life Sciences, Oxford, v.48, p.811-821, 1991.
BRAUNGARTNER, H.R., MUGGLI, R., TSCHOPP, T.B., TURRITO, V.T. Platelet adhesion, release and aggregation in flowing blood: effects of surface properties and platelet function. Thrombosis and Haemostasis, Stuttgart, v.35, p.124-138, 1976.
BROWN, M.S., GOLDSTEIN, J.L. A receptor-mediated pathway for cholesterol homeostasis. Science, Washington, DC, v.232, p.34-47, 1986.
CANNON, P.J. Eicosanoids and the blood vessels wall. Circulation, Dallas, v.70, p.523, 1984.
CHEN, G., SUZUKI, H. Some electrical propeties of the endothelium-dependent hyperpolarization in arterial smooth muscle cells of the rat. Journal of Physiology, London, v.421, p.521-534, 1989.
COCKS, T., ANGUS, J.A. l3ioassay of the release of enc.lothelium-derivec.lrelaxing [actor (EDRF) from isolated endothelial cells in vitro. ln: BEVAN, J.A., GODFRAIND, Y., MAXWELL, R.A., STOCLET, J.S., WORCEL, M. (eds). Vascular neuroeffects mechanisms. Amsterdam: Elsevier, 1985. p.131-136.
DUSTING, G.J ., MONCADA, S, VANE, J.R. Prostaglandins, their intermediates and precursors: cardiovascular actions and regulatory roles in normal and abdominal circulatory systems. Progress in Cardiovascular Diseases, New York, NY, v.21, p.405, 1980.
DYNERMANM, J.L., MEHTA, J.L. Endothelium, platelet and leucocyt interactions in ischem is heart disease: insighs into potentical mechanisms and their clinicai relevance. Journal of the American College of Cardiology, New York, NY, v.16, p.207- 222, 1990.
FURCHGOTT, R.F., ZAWADZKI, J.V. The obligatory role endothelial cells in the relaxition of arterial smooth muscle by acetylcholine. Nature, London, v.288, p.373-376, 1980.
GRIFFITII, T.M., EDWARDS, D.II., LEWIS, M.J. et al. Evidence that cyclic guanosine monosphophate (cGMP) mediates endothelium relaxation. European Journal of Plrarmacology, Amsterdam, v.112, p.195- 202, 1985.
HARKER, LA., FUSTER, R.D., DETWILER, T.C. Pharmacology of platelet inhibitors. Journal of American College of Cardiology, New York, NY, v.8, p.2113-3213, 1986.
KOMURO, I., KURIKAWA, H., SUGIYAMA, T., TAKAFU, F., YASAKI, Y. Endothelin stimulates cfos and c-nycexpression and proliferation of vascular smooth muscle cells. FEBs Letter, Amsterdam, v.238, p.249-252, 1988.
KROLL, M.H., SCHAFER, A.L. Biochemical mechanisms of platelet activation. Blood, Duluth, v.74, p.1181-1195, 1989.
LAIHO, M. KESKI-OJA, J. Growth factores in the regulation of pericellular proteolysis: a review. Cancer Researclr, Baltimore, v.49, p.2433-2553, 1989.
LUSCHER, T.F., BOCK, H.A., YANG, Z. et al. Endothelium-derived relaxing and contracting [actors: perspectives in nephrology. Kidney lnternational, New York, NY, v.39, p.575-590, 1991.
---- DIEDERICH, D. et al. Endothelium dependent responses in carotid arteries of normotensive and hypertension. Hypertension, Dallas, v.11, p.573-578, 1988.
MEHTA, J. Plaquetas and prostaglandins in coronay heart disease: rationale for use of platelet-suppressive drugs. .JAMA, Chicago, v.249, p.2818, 1983.
MEHTA, P., MEHTA, J., LAWSON, D., KROP, L., LETTS, L.G. Leukotrienes potentiate the effects of epinephrine and trombin on human platelet aggregation. Thrombosis Research, Elmsford, v.41, p.731, 1986.
MONCADA, S., VANE, J.R. Physiology in mediei ne arachidonio acid metabolites and lhe interactions betwecn platelets and blood-vassel walls. New Englandlournal of Medicine, Boston, v.298, p.1122, 1978.
MULLANE, K.M., SALMON, J.A., KRAEMER, R. Leukocyte-derived metabolites of arachidonio acid in ischcmic-induced myocardial injury. Pediatric Progress, v.46, p.2422, 1987.
NEEDLEMAN, P., TURK, J., JAKSCHIK, B.A. MORRISON, A.R., LEFKOWITH, J.B. Arachidonic acid metabolism. Annual Review of Bioclremist,y, Palo Alto, v.69, p.102, 1986.
PALMER, R.M., ASIITON, O.S., MONCADA, S. Vascular endothelial cells synthetize nitric oxide [rom L-arginine. Nature, Lonc.lon, v.333, p.664-666, 1988.
PHOL, V., BUSSE, R. Endothelium-dependent modulation of vascular tone and platelet function. European Hearl Journal, London, v.11, p.35-42, supplement B, 1990.
RUBANYI, G.M., LOREMZ, R.R., VANHOUTTE, P.M. Bioassay of endothelium-derivcd relaxing factor(s): inactivation by catecholamines. American lournal of P/rysiology, Bethesda, v.249, p.1195-11101, 1985.
SAKSELLA, O., RIFKIN, D.B. Release of basic fibrobalast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator mediated proteolytic activity. Journal of Cell Biology, New York, NY, v.110, p.767-775, 1990.
VALLANCE, P., COLLER, J., MONCADA, S. Effects of endothelium derived nitric oxide on peripheric arteriolar tone in man. Lancet, London, v.2, p.997-1000, 1989.
VANE, J.R., ANGGARD, E.E., l3OTTING, R.M. Regulatory functions of the vascular endothelium. New England Journal of Medicine, Boston, v.323, p.27-35, 1990.
VERMYLEN,J., VERSTRAETE,M.,PUSTER, V. Role of platelet activation an fibrin formation in thrombogenesis.Journal of the American College of Cardiology, New York, NY, v.8, p.213-913, 1986
VRINTS, G., GERMAN, A.G. Role of cndothelium in the regulation of coronary artery tone. Acta Cardiologica, l3ruxelles, v.46, p.399-418, 1991.
YANAGISAWA, M., KURIHARA, H., KIMURA, S. Et al. A novel potent vasoconstrictor peptide byvascular endothelial cells. Nature, London, v.332, p.411- 415, 1988
