NUTRITION AND AIDS
Keywords:
nutrition, acquired immunodeficiency syndrome, nutrition assessmentAbstract
The human immunodeficiency virus turns the infected individual susceptible to infections and cancer by preventing the adequate immunologic response. The importance of the nutritional status for an human immunodeficiency virus -positive patient is related to its effects on the immunologic system. Malnutrition, a common condition among these patients, also brings about injuries to the immunologic system, having a synergetic effect with the infections. The depletion multicausality of these patients involves the physiopathology of the disease as well as results from the symptoms provoked by medication. The nutritional requirements, energetic, proteic and of antioxidant nutrients like selenium, Zinc, vitamins A, E, C and B, are increasing in response to both opportunistic infections and to human immunodeficiency virus itself. On the other hand, the signs and symptoms related to lead to food intake reduction. A meticulous nutritional evaluation must be made frequently to allow an early intervention in the nutritional status, particularly in children, because it affects development normal course. Even small weight losses (5%), as well as fat-free cell mass, have been associated to bad prognoses. Aggressive nutritional interventions with the use of supplements are many times needed for the patient 's recovery. Although the nutritional deficiency is not considered as the main cause of the immunologic deregulation presented by human immunodeficiency virus-infected individuals, nutritional status quality is an important helping factor in the treatment and life quality improvement of these patients.
Downloads
References
ALA YA, A., CHAUDRY, I.H. Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma. Nutr, London, v11, n1, p1-11, 1995.
ANATOLI, K.et al. Orphans and HIV: 1 infection in a rural population cohort in S.W. Uganda. In: INTERNATIONAL CONFERENCE ON AIDS/ 111 STD WORLD CONGRESS, 8., Amsterdam, 1992. (Abstract PODS 159).
ANTUNES, M.c., SILVA, M.A., LIMA, M.B.C. Manejo terapêutico da desnutrição e consumo em pacientes com AIDS. J Bras Med, Rio de Janeiro, v.66, n.6, p. 125-145, 1994.
ARICO, M.et al. AIDS: outcome of children born to HTLV 111, LAV infected mothers. Helv Acta Paediatr, Olso, v.41, p.477-486, 1986.
AUGUSTO, A.L.P.et al. Terapia nutricional. Rio de Janeiro: Atheneu, 1993.293p.
BALL, C. S. Global issues in pediatric nutrition: AIDS. Num London, v. 14, n. 10, p.767-770, 1998.
BARUCHEL, S. et al. Nutriceutical modulation of glutathione with a humanized native milk serum protein isolate, Immunocaltn : application in AIDS and cancer.ln.• MONTAGNIER, L., OLIVIER, R., PASQUIER, C. (Ed.). Oxidative stress in cancer, AIDS and neurodegenerative diseases. New York: Marcel Dekker, 1998. cap: 42, p.447-549.
BATES, C.M. HIV medicine: drug side effects and interactions. Postgrad MedJ, London, v.72, n. 1, p.30-36, 1996.
BAUM, M.K., SHOR-POSNER, G. Nutritional status and survival in HIV-I disease. AIDS, Philadelphia, v11, n.3, p.690-691,1997.
BAUM, M.K. et al. High risk of HIV-relative mortality is associated with selenium deficiency. J Acquir imune Defic Syndr Hum Retrovirology, v. 15, n.5, p.370-374, 1997.
BEISEL, W.R. Nutrition and immune function: overview. J Nutr, Bethesda, v. 126 (Supplement 10), p.2611 s-2615S, 1996.
BELL, S.J. et al. Body composition changes in patients with immunodeficiency virus infection. Nutr, London, v. 13, n.7/8, p.629-632, 1997.
BERNEIS, K. etal. Nutritional supplements combined with dietary counselling diminish whole body protein catabolism in HIV-infected patients. Eur J Clin Invest, Oxford, v.30, n. l , p. 87-94, 2000.
BITHONEY, w.G., NEWBERGER, E.H. Child and family attributes of failure-to-thrive. J Dev Behav Pediatr, Baltimore, v.8, p.32, 1987.
BOND, L., LONGSHORE, D. The role of injection substance use in influencing HIV/STD risk behavior in four American countries. ln: BOND, L. (Org.). A portfolio of AIDS/DST Behavior Interventions and Research. Washington DC Pan American Health Organization, 1992. p.209215.
BOSWELL, s.L., HIRSCH, M.S. Therapeutic approach to the HIV-seropositive patient. ln: De VITTA Jr. et al. AIDS: etiology, diagnosis, treatment, and prevention. 3.ed. Philadelphia: J.B. Lippincott, 1992. p.424-425.
BOUNOUS, G. et al. Whey proteins as a food supplement in HIV-seropositive individuals. Clin Invest Med, Toronto, v. 16, n.3, p.204-209, 1993.
BRASIL. Ministério da Saúde. Divisão Nacional de Doenças Sexualmente Transmissíveis AIDS: Boletim Epidemiológico, Brasília, v.9, n.6, 1997a. 31p.
BRASIL. Ministério da Saúde. AIDS: Boletim Epidemiológico, Brasília, v. 10, n.3, p. 1 8, 1997b. (Semana Epidemi016gica —junho a agosto).
BRASIL. Ministério da Saüde. AIDS: Boletim Epidemioldgico, Brasilia, v. 11, n.3, 1998. (Semana Epidemi016gica 22 a 34).
BRASIL. Ministério da Såude. AIDS: Boletim Epidemiolögico, Brasilia, v. 12, n.3, p. 37, 1999. (Semana Epidemi016gica —junho a agosto).
BUHL, R. et al. Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet, London, v.2, n.8675, p. 1294-1298, 1989.
CANALS, M.J., SOLER, F.J. Nutrition and aids in the pediatric patient: a review. Ped Nut ISPEN, v. 1 , n.2,p.6-16, 1999.
CENTERS FOR DISEASE CONTROL. HIV/AIDS. Surveillance Report, v.5, p. 1-19, 1993.
CENTERS FOR DISEASE CONTROL. 1994 Revised classification system for human immunodeficiency virus (HIV) infection in children less than 13 years of age. MMWR, Atlanta, v.43, p.1-10, 1994.
CHANDRA, R.K., KUMARI, S. Effects of nutrition on the immune system. Nutr, London, v. 10, n. 3, p.207-210, 1994.
CHANG, J. et al. Alterations in body composition in HIV- 1 infection. J Am Diet Assoc, Chicago, v.91 , n.9, p.28S, 1991. Supplement.
CHARMY, A., LUDMAN, E.K. Treating malnutrition in AIDS: comparison of dietetians ' practices and nutrition care guidelines. J Am Diet Assoc, Chicago, 1991.
CHEN, C.Y.etal. Effect of selenium supplementation on mice infected with LP-BM5 MuLV, a murine AIDS model. Biol Trace Elem Res, London, v.59, n1/3, p.187-193, 1997.
CHIN, J. Epidemiology: current and future dimensions of the HIV/AIDS pandemic in women and children. Lancet, London, v.336, p.221-224, 1990.
CONNOR, E.M. et al. Reduction of maternal infant transmission of HIV type 1 with zidovudine treatment. N Engl J Med, Boston, v.331, p. 1173- 1180, 1994.
ECHEVERRIA, P.S.eta1. Perception of quality of life of persons with HIV/AIDS and maintenance of nutritional parameters while on protease inhibitors. AIDS Patient Care STDs, v.13, n.7, p.427-433, 1999.
ESCOTT-STUMP, S. Nutrição relacionada ao diagnóstico e tratamento. Manole: São Paulo, 1999.760p.
EVANS, w.J., ROUBENOFF, R., SHEVITZ, A. Exercise and the treatment of wasting: aging and human immunodeficiency virus infection. Semin Oncol, Philadelphia, v.25, n.2 (Supplement 6), p. 112s-122S, 1998.
FALLOON, J. etal. Infectious complication of HIV. In: De VITTA Jr. al. AIDS: etiology, treatment, and prevention. 3.ed. Philadelphia J.B. Lippincott, 1992. p. 157-225.
FENNOY, 1., LEUNG, J. Refeeding and subsequent growth in the child with AIDS. Nutr Clin Pract, v.5, p.54-58, 1990.
FERRINI, M. T. et al. Efeitos do suporte nutricional na sobrevida dos pacientes com AIDS-IV C.Rev Hosp Clin Fac Med Säo Paulo, Säo Paulo, v.48, n4, p161-166, 1993.
FIELDS-GARDNER, C., AYOOB, K.T. Position of Dietitians of Canada and the American Dietetic Association: nutrition intervention in the care of persons with humans immunodeficiency virus Inection. Can J Diet Pract Res, v.61, n.2, p. 77-87, 2000.
FOWLER, M.G.,ROGERS, M.F. Overview of perinatal HIV infection. J Nutr, Bethesda, v. 126, p.2602S- 2607S, 1996.
GOMEZ-CANDELA, C. et al. Nutritional status in HIV/AIDS outpatients of Spain. Nutr, London, v13, n.3, p.271,1997.
GRIMBLE, R.F. Modification of inflammatory aspects of immune function by nutrients. Nutr Res, Elmsford, v.18, n.7, p. 1297-1317,1998.
HALSEY, N.A. et al. Transmission of HIVI Infections from mothers to infants in Haiti. J Am Med Assoc, Chicago, v.264, n. 16, p.2088-2092, 1990.
HASSIG, A. etal. The role ofthe Thi to Th2 shift of the cytokine profile of CD4 helper celss in the patogenesis of autoimmune and hipercatabolic disease. Med Hypotheses, Harlow, v,51 , n. 1 , p .59 63, 1998.
HECKER, L.M., KOTLER, D.P. Malnutrition in patients with AIDS. Nutr Rev, New York, v,48 n.11, p.393-399, 1990.
HERZENBERG, L.A.eta1. Glutathione deficiency is associated with impaired survival in HIV disease. Am J Med Sci, Hagerstow, v.94, n.8, p. 1967-1972, 1997.
HYMAN, C., KAUFMAN, S. Nutritional impact of acquired immune deficiency syndrome: a unique counseling opportunity. J Am Diet Assoc, Chicago, v.89, p.520-527, 1989.
JACOBS, D.O. Bioelectrical impedance analysis: a way to assess changes in body cell mass in patients with acquired immunodeficiency syndrome. J Parent Ent Nutr, v. 17, n.5, p.401402, 1993.
JIMENEZ-EXPOSITO, M.J. et al. Effect of malabsorption on nutritional status and resting energy expenditure in HIV-infected patients. AIDS, Philadelphia, v. 12, n. 15, p. 1965-1972, 1998.
KOCH, J. et al. Steatorrhea is nearly universal in patients with HIV-associated unexplained weight loss or diarrhoea.Nutr, London, v. 13, n.3, p.268, 1997.
KOCH, J. The role of body composition measurements in wasting syndromes.Semin Oncol, Philadelphia, v.25, n.2, (Supplement 6), p. 12S-19S, 1998.
KOTLER, D.P.etal. Preservation ofshort-term energy balance in clinically stable patients with AIDS. Am JC1in Nutr, Bethesda, v.51, p.7-13, 1990.
KOTLER, D.P.eta1. Prediction of body cell mass, fat free mass, and total body water with bioeletrical impedance analysis: effects of race, Sex and disease. Am J Clin Nutr, Bethesda, v.64, p.489S497S, 1996. Supplement.
KOTLER, D.P. Human immunodeficiency virusrelated wasting: malabsortion syndromes.Semin oncol, Philadelphia, v.25, n.2, p. 70-75, 1998.
KOTLER, D.P.et al. Relative influences ofsex, race, environment, and HIV infection on body composition in adults.Am J Clin Nutr, Bethesda, v.69, n.3,p.432-439, 1999.
LAUE, L. et al. Growth and neuroendocrine dysfunction in children with acquired immunodeficiency syndrome. J Pediatr, St. Louis, v. 117, n.4,p.541-545, 1990.
LEANDRO-MERHI, V.A. et al. Evolution of nutritional status of infants infected with the human immunodeficiency virus. Säo Paulo Med J, Säo Paulo, v. 1 1 8, n.5, 2000. (In press).
LIANG, B.et al. Vitamins and immunomodulation in AIDS.Nutr, London, v. 12, n. 1, p. 1-7, 1996.
LIMA, H.s., SEVÅ-PEREIRA,A. AIDS, diarréiaemå absorqäo de lactose.Rev Bras Med, Rio de Janeiro, v.49, n.7,p.411-422, 1992.
LOOK, M.P.etal. Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)- levels in asymptomatic versus symptomatic human immunodeficiency virus-I (HIV -1) Nutr, London, v.51 n.4, p.266-272, 1997.
MACALLAN, D.C. Nutrition and immune fimction in human immunodeficiency virus infection. Proc soc, London, v.58, n.3, p.743-748, 1999a.
MACALLAN, D.C. Wasting in HIV infection and AIDS.JNutr, Bethesda, v. 129, n. 1,p.238S-242S, 1999b. Supplement.
MARMOR, M. et al. Weight loss associated with HIV seroconversion among inj ection-drug users. JA cquirlmmune Defic Syndr Hum Retrovirology, v. 12, n.5,p.514-518, 1996.
MATARAZZO, P. et al. Growth impairmen, IGF-I hyposecretion and thyroid dysfunction in children with perinatal HIV-I infection. Acta Paediatr, v.83,p.1029-1034, 1994.
Mc KINNEY, R.E., WILFERT, C. AIDS Clinical Trials Group Protocol 043 Study Group. Growth as a prognostic indicator in children with human immunodeficiency virus infection treated with zidovudine. J Pediatr, St. Louis, v. 125, n.5, p.728-733, 1994.
McCORKINDALE, C. et al. Nutritional status of HIV-infected patients during the early disease stages. J Am Diet Assoc, Chicago, v.90, n.9, p.1236-1241,1990.
McMAHON, K., DECKER, G., OTERRY, F.D. Integrating proactive nutritional assessment in clinical practices to prevent complications and cost. Semin Oncol, Philadelphia, v.25, n.2, (Supplement 6), p.20-27, 1998.
MILLER, T.L. et al. Malnutrition and carbohydrate malabsorption in children with vertically transmitted human immunodeficiency virus. 1: Infection. Gastroenterology, Philadelphia, v. 100, n.5,p.1296-1302, 1991.
MILLER, T.L. et al. Growth and body composition in children infected with the humam immunodeficiency virus - 1. Am J Clin Nutr, Bethesda, v.57, p.588-592, 1993,
MOHS, M.E., WATSON, R.R., LEONARD-GREEN, T. Nutritional effects ofmarijuana, heroin, cocaine, and nicotine. JAm DietAssoc, Chicago, v .90, n. 9, p. 1261-1267, 1990.
MOYE, J. et al. Natural history ofsomatic growth in infants born to women infected by human immunodeficiency virus. J Pediatr, St. Louis, 1996.
MULLIGAN, K., TAI, V.W., SCHAMBELAN, M. Use ofgrowth hormone and other anabolic agents in AIDS wasting.JParentl Enter Nutr, v.23, n. 6, p.S202-S209, 1999.
MURATA, H., HRUZ, P.w., MUECKLER, M. The mechanism of insulin resistance cause by HIV protease inhibitor therapy. J Biol Chem, Baltimore, v.275, n.27,p.20251-20254, 2000.
MUURAHAINEN, N. et al. Trends ins weight and body mass (BCM) changes in HIV-infected men. Nutr, London, v. 13,
NAKATANI, T. et al. Apoptose induced by chelation of intracellular zinc is associated with depletion of cellular reduced glutathine level in rat hepatocytes. Chem Biol Interact, Limerick, v. 125,
NEGRA, M.D. et al. Manejo clinico da AIDS pediåtrica. Säo Paulo : Atheneu, 1998. p.6-10.
NEMECHEK, P.M., POLSKY, B., GOTTLIEB, M.S. Treatment guidelines for HIV-associated wasting. Mayo Clin Proc, Rochester, v.75, n.4, p.3 86-394, 2000.
NICHOLS, W.S.eta1. Increased CD4+T-Lymphocyte senescence fraction in advanced human immunodeficiency virus type 1 infection. Scand Jlmmunol, Oxford, v.49, n.3, p.302-306, 1999.
NIYONGABO, T. et al. Comparison ofmethods for assessing nutritional status in HIV-infected adults.Nutr, London, v. 15, n. 10, p. 740-743, 1999.
NYLÉN, G. et al. Mortality in young adults in England and Wales : the impact ofthe HIV epidemic .AIDS, Philadelphia, v. 13, n. 12, p. 1535-1542, 1999.
OCKENGA, J., MANNS, M.P. The impact ofbody composition analysis in HIV-infected patients: quantifying therapeutic effects. AIDS, Philadelphia, v. 13, n.2, p.279-280, 1999.
OLESKE, J. et al. Immune deficiency syndrome In children.JAm MedAssoc, Chicago, v.249, p.23452349, 1983.
OLESKE, J.M. The many needs ofthe HIV: infected child.Hosp Pract, New York, v.29, n.9, p.81-87, 1994.
OLESKE, J.M., ROTHPLETZ PUGLIA, P.M., WINTER, H. Historical perspectives on the evolution in understanding the importance of nutritional care in pediatric HIV infection.JNutr, London, v. 126, p.2616S-2619S, 1996.
ORGANIZACIÖN MUNDIAL DE LA SALUD. La higiene de los alimentos puede salvar vidas. Foro Mundial de la Salud , v. 12, p.421-423, 1991,
OTTERY, F.D., WALSH, D., STRAWFORD, A. Pharmacologic management ofanorexia/cachexia. Semin Oncol, Philadelphia, v.25, n.2, (Supplement 6), p.35S-44S, 1998.
PALENICEK, J.P. et al. Weight loss prior to clinical AIDS as a predictor of survival. AIDS, Philadelphia, v. 10, n.3, p.366-373, 1995.
PATON, N.I.J. et al. Longitudinal changes in body composition measured with a variety ofmethods in patients with AIDS. J Acquir Immune Defic SyndrHum Retrovirol, v. 14, n.2, p. 1 19-127, 1997.
PECKHAM, C., GIBB, D. Motherto child transmission of the human immunodeficiency virus. N Engl J Med, Boston, v.333, 11.5, p.298-302, 1995.
PERNERSTORFER-SCHOEN, H. et al. Benefical effects ofprotease inhibitors on body composition and energy expenditure: a comparision between HIV-infected and AIDS patients. AIDS, Philadelphia, v. 1 3, n. 17, p.2389-2396, 1999.
PHARO, A. et al. A comprehensive program to reverse/prevent wasting syndrome in HIV/AIDS patients. Nutr, London, v. 1 3, n.3, p.280, 1997.
PICHARD, D. et al. A randomized double-blind controlled study of 6 months of oral nutritional supplementation with arginine and W-3 fatty acids in HIV-infected patients.AIDS, Philadelphia,
QUINTAES, K.D., GARCIA, R.W. D. Adesäo de pacientes HIV positivos å dietoterapia ambulatorial.RevNutr, Campinas, v. 12, n.2, p. 175181, 1999.
RABAUD, C.etal. Free radicals during HIV infection. Ann Biol Clin, Paris, v.55, n.6, , 1997.
RAYMAN, M.P. The importance of selenium to human health. Lancet, London, v.365, n.9225, p.233-241, 2000.
RAZZINI, E., BARONZIO, G.F. Omega-3 fatty acids as coadjuvant treatment in AIDS. Med Hypotheses, Harlow, v.41, n.4, p.300-305, 1993.
RESLER, S. Nutrition care of AIDS patients. JAm DietAssoc, Chicago, v.88, p. 828-832, 1988.
RICH, K. et al. Natural history of somatic growth in pediatric HIV infection: preliminary data of the women and infants transmission study (WITS). Natl ConfHum Retroviruses Relat Infect, v. 180, (Supplement l) p. 12S-16S, Dec. 1993.
ROMERO-ALVIRA, D., ROCHE, E. The key of oxidative stress in acquired immune deficiency syndrome apoptosis. Med Hipotheses, Harlow, 1998.
RUBINSTEIN, A.et al. Acquired immunodeficiency with reversed T4/T8 ratios in infants born to promiscuous and drug addicted mothers. J Am MedAssoc, Chicago, v.249, p.2350-2356, 1983.
SANTOS, J. et al.. Nutritional status in hospitalizes patients with HIV infection.Nutr, London, v. 13 , n.3,p.278, 1997.
SCHWENK, A. et al. Bioeletrical impedance analysis in HIV-infected patients treated with triple antiretroviral treatment. Am J Clin Nutr, Bethesda, v. 70, n.5, p. 867-873, 1999.
SCOTT, G.B. et al. Acquired immunodeficiency syndrome in infants. N Engl J Med, Boston, v.310, p.76-81, 1984.
SCOTT, G.B. et al. Survival in children with perinatally acquired human immunodeficiency virus type I infection. N Engl J Med, Boston, v.321, n.26, p.1791-1796,1989.
SEN, C.K. Nutritional biochemistry of cellular glutathione. J Nutr Biochem, Syoneham, v.8, n. 12, p.660-672, 1997.
SHABERT, J.K. et al. Glutamine-antioxidante supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial.Nutr, London, v. 15, n. 11/12, p.860-864, 1999.
SHARPSTONE, D.etal. The influence of nutritional and metabolic status on progression from asymptomatic HIV infection to AIDS defining diagnosis.AIDS, Philadelphia, v. 13, n. 10, p. 12211226, 1999.
SHERER, R. Current antiretroviral therapy and its impact on Humana Immunodeficiency Virus Related wasting. Semin Oncol, Philadelphia, v.25, n.2, (Supplement 6), p.92S-97S, 1998.
SHIKUMA, C.M. et al. Fasting hiperinsulinemia and increase waist-to-rip ratios in non wasting individuals with AIDS .AIDS, Philadelphia, v. 13 ,
SINGER, P. et al. Nutritional aspects of the acquired immunodeficiency syndrome. Am J Gastroenterol, New York, v.87 , n.3, p.265-273, 1992.
SLUYS, T.E.M.S.eta1. Body composition in patients with acquired immunodeficiency syndrome: a validation study ofbioeletric impedance analysis. v. 17, n.5, p.404-406, 1993. 111. SPADA, C., TREITINGER, A., HOSHIKAZA-
FUJIMURA, A.Y. HIV influence on hematopoiesis at the initial stage of infection. EurJHaematol, Copenhagen, v.61, n.4, p.255260, 1998.
SPRIETSMA, J. Cysteine, Glutathione (GSH) and zinc and copper ions together are effective natural, intracellular inhibitors of(AIDS) viroses. Med Hypotheses, Harlow, v.52, n.6, p.529-538, 1999a.
SPRIETSMA, J. Modern diets and diseases: Nozinc balance — under Thl, zinc and nitrogen mon6xido (NO) collectively protect aagains viruses, AIDS, autoimmunity, diabetes, allergies, asthma, infectious diseases, artherosclerosis and cancer. Med Hypoteses, Harlow, v.53, n. 1, p.6-16, 1999b.
STRAWFORD, A., HELLERSTEIN, M.The etiology ofwasting in the human immunodeficiency virus and acquired immunodeficiency syndrome. Semin in Oncol, Philadelphia, v.25, n. 13, p. 76 81, 1998.
SZWARCWALD, C.L. et al. A disseminação da AIDS no Brasil, no periodo de 1987-1996: uma análise espacial. Cad Saúde Públ, Rio de Janeiro, v. 16 (Suplement 1), p.7S-19S, 2000.
THEA, D.M. et al. A prospective study of diarrhea and HIV-I infection among 429 Zairian infants. NEng1JMed, Boston, v.329,p.1696-1702, 1993.
THULER, L.C.S., VAZ, L.F.G. HIV. J Bras Med, Rio de Janeiro, v.66, n.3, p.85-108, 1994.
TOVO, P.A.et al. Prognostic factors and survival in children with perinatal HIV- 1 infection.Lancet, London, v.339, n.23,p.1249-1523, 1992.
VANHEMS, P., BEAULIEU, R. Primary infection by type I human immunodeficiency virus: diagnosis and prognosis. Postgrad Med, Minneapolis, v.73, n.3,p.403-408, 1997.
WANKE, C. Single-agent/combination therapy of human immunodeficiency virus-related wasting. Semin Oncol, Philadelphia, v.25, n.2 (Supplement 6), p.98S-103S, 1998.
WHEELER, D.A.et al. Weight loss as a predictor of survival and disease progression in HIV infection.AIDS, Philadelphia, v. 18, p. 80-85, 1998.
WILLIAMS, B., WALTERS, D., PARKER, K. Evaluation and treatment ofweght loss in adults with HIV disease. Am Fam Physician, Kansas City, v.60, n.3, p.843-854, 1999.
WINTER, H.S. MILLER, T.L. Gastrointestinal and nutritional problems in pediatric HIV disease. In: PIZZO, P.A., WILFER, C.M.PediatricAIDS: the challenge of HIV infection in children and adolescent. 2.ed. Baltimore : Willians & Wilkins, 1994. p. 513-534.
WORLD HEALTH ORGANIZATION. The HIV/ AIDSpandemic: 1993 Overview. Geneva, 1993.
YEH, K.C. et al. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents and Chemother, Washington DC, v.42, n.2,p.332-338, 1998.
YSSELDYKE, L.L. Nutritional complications and incidence ofmalnutrition among AIDS patients. JAm Diet Assoc, Chicago, v.91 , n.9, p.217-218, 1991.
ZANUSSI, S. al. The effects ofCD40 ligation on peripheral blood mononuclear cell interleukin-12 and interleukin-15 production and on monocyte CD14 surface antigen expression in human immunodeficiency virus-positive patients. Scand J Immunol, Oxford, v.49, n.3, p.286-292, 1999.