NEONATAL OUTCOMES AFTER EPIDURAL ANALGESIA WITH LOW DOSES OF BUPIVACAINE AND SUFENTANIL OR PLACEBO: A DOUBLE-BLIND STUDY
estudo duplo-cego
Keywords:
obstetrical analgesia, bupivacaine, sufentanil, neonatal outcomesAbstract
objective
To evaluate the safety of the combination of bupivacaine and sufentanil during epidural analgesia for labor and delivery, in relation to neonates.
Methods
A double-blind, randomized clinical trial was carried out on 60 nulliparous women. Pregnant women admitted to the Maternity Unit of the Center for Comprehensive Attention to Women's Health, State University of Campinas were randomly distributed into two groups: Group BS received 12.5 mg of bupivacaine plus 30 ug of sufentanil and Group BP received 12.5 mg of bupivacaine plus placebo epidurally. All subsequent doses were 10 ml of 0.125% bupivacaine. Parameters related to possible effects on the neonate were then evaluated.
Results
There was no difference between the two groups in relation to the neonate. The newborns were considered equally vigorous not only in relation to the Erasure Index, but also in terms of cord blood gas analysis and neurobehavioral assessment.
Conclusion
The addition of 30 sufentanil to the first dose of bupivacaine with the aim of improving the quality of labor analgesia does not affect the neonatal outcome.
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References
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