Sexual Behaviour Ano Age As Risk Factors For Intraepithelial And Invasive Uterine Cervical Lesion
Keywords:
uterine cervical, sex behavior, intraepithelial lesionAbstract
Objective
To evaluate the association between some socio-demographic and reproductive factors and the presence of cervical injuries.
Methods
In this cross-sectional study, 2281 women were included, who, after answering a questionnaire, underwent oncological cytology collection, li-hybrid capture and visual inspection of the cervix with 5% acetic acid. Women with at least one positive test were invited for colposcopy. The association of socio-demographic and reproductive factors with the results of the exams and histological diagnosis was evaluated by calculating the odds ratio and stepwise logistic regression.
Results
Oncological cytology was abnormal in 209 (9.2%) women, li hybrid capture was positive in 399 (17.5%) and VAT was abnormal in 249 (10.9%). Among the 2281 women evaluated, 671 (29.4%) had at least one positive test result, although only 82 (3.6%) had disease (50 CIN 1, 20 CIN2, seven CIN3 and five invasive carcinomas). Age under 35, not living with a partner, early onset of sexual activity and the number of partners in the last year were significantly associated with at least one positive test result. Age under 35 years was associated with histological disease.
Conclusion
Living without a partner, early onset of sexual activity and the number of partners can act as indicators of cervical injury, although in this population, as it includes a large proportion of CIN 1, only age under 35 years was associated with histological disease.
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References
Instituto Nacional do Câncer. Programa Nacional de Controle do Câncer do Colo do útero e de Mama - Viva Mulher. [Acesso em: 22 agosto] 2003. Disponível em: http://www.inca.gov.br
Franco EL, Villa LL, Ruiz A, Costa MC. Transmission of cervical papillomavirus infection by sexual activity: differences between low and high oncogenic risk types. JID 1995; 172: 756-63.
Bosch FX, Franco E. Cervical Cancer Contrai, Priorities and New Directions. Paris, 2003. lnternational Charter. HPV and Cervical Cancer. Epidemiology, 4-7.
Deacon JM, Evans CD, Yule R, et ai. Sexual behaviour and smoking as determimants of cervical HPV infection and of CIN3 among those infected: a case-contrai study nested within the Manchester cohort. Br J Cancer 2000; 83 (11):1565-72.
Walboomers JM, Jacobs MV, Manos MM, et ai. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999; 189(1 ): 12-9.
Atalah SE, Urteaga CR, Rebolledo AA, Villegas RA, Medina EL, Csendes AJ. Alimentación, tabaquismo e historia reproductiva como factores de riesgo dei cáncer de cuello dei útero. Rev Méd Chile 2001; 129:597-603.
Kjellberg L, Hallmans G, Ahren A-M, et ai. Smoking, diet, pregnancy, and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection. Br J Cancer 2000; 82 (7): 1332-8.
Syrjanen KJ, Syrjanen SM. HPV typing as an adjunct to cervical cancer screening. Cytopathol 1999; 10:8-15.
Belinson J, Qiao YL, Pretorius R, et ai. Shanxi province cervical cancer screening study: a crosssectional comparative triai of multiples techniques to detect cervical neoplasia Gynecol Oncol 2001; 83:439-44.
Blumenthal P, Gaffikin L, Chirenje ZM, Mcgrath J, Womack S, Shah K. Adjunctive testing for cervical cancer in low resource settings with visual inspection, HPV and Pap smear. lnt J Gynecol Obstet 2001; 72:47-53.
Clavel C, Masure M, Bory JP, et ai. Human papillomavirus testing in primary screening for detection of high-grade cervical lesions: a study of 7932 women. Br J Cancer 2001; 89:1616-22.
Kurman RJ, Solomon D. The Bethesda System for reporting cervical/vaginal cytologic diagnoses. New York: Springer-Verlag 1994, 81 p.
Blumenthal P. Atlas for Unaided Visual lnspection of the Cervix. Baltimore: JHPIEGO; 1997.
Stafl A, Wilbanks GD. An international terminology of colposcopy: report of the Nomenclature Committee of the lnternational Federation of Cervical Pathology and Colposcopy. Obstet Gynecol 1991; 77:313-4.
Syrjanen KJ, Syrjanen SM. Papillomavirus infections in human pathology. Chichester: Wiley; 2000, p.615.
Brito NMB, Moreira SFS, Ferreira MA, Lopes RV, Bastos AAC. Aspectos epidemiológicos das neoplasias intraepiteliais cervicais identificadas por citologia oncótica. Rev Para Med 2000; 14:42-6.
Kotloff K, Wasserman SS, Russ K, et ai. Detection of genital human papillomavirus and associated cytological abnormalities among college women. Sex Trans Dis 1998; May:243-50.
Leal EAS, Leal Júnior OS, Guimarães MH, Vitoriano MN, Nascimento TL, Costa OLN Lesões precursoras do câncer de colo em mulheres adolescentes e adultas jovens do município de Rio Branco - Acre. RBGO 2003; 25(2):81-6.
Bosch FX, Munõz N, Sanjosé S. Human papillomavirus and other risk factors for cervical cancer. Bio & Pharm 1997; 51:268-75.
Derchain SFM, Roteli-Martins CM, Syrjanen KJ, Abreu HI, Martinez EZ, Alves VAF. Association of oncogenic human papillomavirus HPV- DNA with high grade cervical intraepithelial neoplasia (CIN 2 or 3): the role of cigarette smoking. Sex Trans lnf 1999; 75(6):406-8.
Josefsson AM, Magnusson PK, Ylitalo N, et ai. Virai load of human papillomavirus 16 as a determinant for development of cervical carcinoma in situ: a nested case-contrai study. Lancet 2000; 355:2819-93.
Eluf-Neto J, Nascimento CMR Cervical cancer in Latin América. Sem Oncol 2001; 28(2):188-97.
Moreno V, Bosch FX, Munõs N, et ai. Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-contrai study. Lancet 2002; 359: 1085-92.