Wound healing in patellar tendon after graft Removal for reconstruction of the knee ligament Participation of growth factors
Keywords:
ligament injury, patellar tendon, growth factors, tendon wound healingAbstract
Knee ligament injuries are common among those who practice physical activity, and can affect the intra-articular ligaments (anterior cruciate ligament, posterior cruciate ligament) and extra-articular ligaments (medial collateral ligament and lateral collateral ligament). The ligament reconstruction technique using the patellar tendon has been used with good results, with the healing of this tendon being a complex but orderly process, involving several regulatory agents. It begins with an inflammatory process that, through chemical signals, stimulates the production of polypeptide growth factors. The most important growth factors in the repair of the patellar tendon tissue are: epidermal growth factor, platelet-derived growth factor, fibroblast growth factor, alpha and beta transformation and growth factors, and various cytokines. These factors stimulate the proliferation of fibroblasts, synthesis of collagen and other connective tissue molecules. In this review, our objective was to describe the sequence of events that occur during the healing of the patellar tendon after graft removal for knee ligament reconstruction, focusing on the growth factors that play an important role in regulating the process.
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