Esthesioneuroblastoma
Keywords:
Esthesioneuroblastoma olfactory, Head and neck neoplasms, Nose neoplasms, Paranasal sinusesAbstract
Esthesioneuroblastoma is an uncommon malignant neoplasm that arises from the
olfactory epithelium and corresponds to 4% - 6% of all malignant tumors in the
paranasal sinuses. The last extensive review on these tumors reveals that less than one
thousand cases have been published in the literature since its discovery eighty years
ago. The common clinical manifestations are anosmia, nasal obstruction and epistaxis.
Since its microscopic characteristics vary greatly and are unspecific, a precise diagnosis
using histochemical and immunohistochemical techniques cannot be overemphasized
as the patient’s prognosis depends on the diagnosis. As it is a rare disease, there is no
consensus regarding the best treatment, but reports of cases treated successfully cite
a multidisciplinary approach, which includes chemotherapy, surgical resection and
radiation therapy. Our service has treated four cases over a period of six years (January
2000 - January 2006) that are reported here.
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References
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