Desnutrição protéica no início da vida prejudica memória social em ratos adultos

Autores

  • Viviane Consiglio da SILVA Universidade de São Paulo
  • Sebastião de Sousa ALMEIDA Universidade de São Paulo

Palavras-chave:

desnutrição protéica, comportamento social, ratos

Resumo

Objetivo
Avaliar se a desnutrição protéica imposta no início da vida produz prejuízos em um procedimento experimental de memória social em ratos (Rattus norvegicus).

Métodos
Os animais receberam dietas isocalóricas contendo 6% ou 16% de proteína do nascimento aos 21 dias, e dieta comercial a partir de 22 dias de idade. O teste de memória social consistiu em, após duas sessões de habituação (7 minutos/sessão), introduzir um animal adulto (100-114 dias de idade) e um outro jovem (30-44 dias de idade) em uma arena de acrílico (90cm x 90cm x 45cm) em duas sessões separadas por intervalos de 30 (experimento 1) ou 15 minutos (experimento 2). O contato social foi definido como investigação (ato de cheirar/inspecionar a região anogenital). A diferença no tempo de contato entre a primeira e a segunda exposição é considerada um índice de memória social.

Resultados
Nenhuma diferença devida à dieta foi observada no experimento 1. No experimento 2 houve redução no tempo de contato social dos animais-controle da primeira para a segunda exposição (p<0,05) e não houve alteração nos animais desnutridos.

Conclusão
Esses resultados sugerem que a desnutrição protéica precoce prejudica a memória social de ratos adultos.

Referências

Meeks Gardner, Grantham-McGregor SM, Chang SM, Himes JH, Powell CA. Activity and behavioral development in stunted and non-stunted children and response to nutritional supplementation. Child Dev. 1995; 66(6):1785-97.

Dobbing J. Early nutrition and later achievement. London: Academic Press; 1987.

Lima JG, Oliveira LM, Almeida SS. Effects of early concurrent protein malnutrition and environment stimulation on the central nervous system and behavior. Nutr Neurosci. 1999; 1:439-48.

Morgane PJ, Austin K, Lafrance RJ, Bronzino JD, Tonkiss J, Diaz-Cintra S, et al. Prenatal malnutrition and development of the brain. Neurosci Biobehav Rev. 1993; 17(1):91-128.

Strupp BJ, Levitsky DA. Enduring cognitive effects of early malnutrition: a theoretical reappraisal. J Nutr. 1995; 125(8 Suppl):2221S-32S.

Almeida SS, Tonkiss J, Galler JR. Malnutrition and reactivity to drugs acting in the central nervous system. Neurosci Biobehav Rev. 1996; 20(3): 389-402.

Galler JR, Shumsky JS, Morgane PJ. Malnutrition and brain development. In: Walker WA, Watkins J, editors. Nutrition in Pediatrics. 2nd ed. Neuilly Sur-Seine, France: Plenum Press; 1996. p.194-210.

Almeida SS, Paiva RVS, Araújo M, Moreira GMS, Oliveira LM. Short-term social isolation does not reduce the elevated plus-maze exploration in early protein malnourished rats. Nutr Neurosci. 1998; 1:103-10.

Tonkiss J, Galler JR, Formica RN, Shukitt-Hale B, Timm RR. Fetal protein malnutrition impairs acquisition of a DRL task in adult rats. Physiol Behav. 1990; 48(1):73-7.

Córdoba NE, Arolfo MP, Brioni JD, Orsingher OA. Perinatal undernutrition impairs spatial learning in recovered adult rats. Acta Physiol Pharmacol Ther Latinoam. 1994; 44(3):70-6.

Castro CA, Tracy M, Rudy JW. Early-life undernutrition impairs the development of the learning and short-term memory processes mediating performance in a conditional-spatial discrimination task. Behav Brain Res. 1989; 32(3):255-64.

Almeida SS, Araujo M. Postnatal protein malnutrition affects play behavior and other social interactions in juvenile rats. Physiol Behav. 2001; 74(1-2):45-51.

Fukuda MT, Françolin-Silva AL, Almeida SS. Early postnatal protein malnutrition affects learning and memory in the distal but not in the proximal cue version of the Morris water maze. Behav Brain Res. 2002; 133(2):271-7.

Becker A Grecksch G. Social memory is impaired in neonatally ibotenic acid lesioned rats. Behav Brain Res. 2000; 109(1):137-40.

Reijmers LG, Leus IE, Burbach JP, Spruijt BM, van Ree JM. Social memory in the rat: circadian variation and effect of circadian rhythm disruption. Physiol Behav. 2001; 72(3):305-9.

Almeida SS, Garcia RA, Cibien MMR, De Araújo M, Moreira GMS, De Oliveira LM. The ontogeny of exploratory behaviors in early protein malnourished rats exposed to the elevated plus-maze test. Psychobiology. 1994; 22:283-8.

Araújo M, Almeida SS. Ontogeny of home-orienting behavior in rat pups during the first half of the lactation period: effects of early postnatal protein malnutrition on repeated but not single testing. Nutr Neurosci. 2000; 2:425-33.

Almeida SS, Tonkiss J, Galler JR. Prenatal protein malnutrition affects the social interactions of juvenile rats. Physiol Behav. 1996; 60(1): 197-201.

Bedi KS. Spatial learning ability of rats undernourished during early postnatal life. Physiol Behav. 1992; 51(5):1001-7.

Clarke KA, Parker AJ, Smart JL. Analysis of walking locomotion in adult female rats undernourished as sucklings. Physiol Behav. 1992; 52(4):823-6.

Loranca A, Torrero C, Salas M. Development of play behavior in neonatally undernourished rats. Physiol Behav. 1999; 66(1):3-10.

Meaney MJ, Stewart J. A descriptive study of social development in the rat (Rattus norvegicus). Anim Behav. 1981; 29:34-45.

Whatson TS, Smart JL, Dobbing J. Dominance relationships among previously undernourished and well fed male rats. Physiol Behav. 1975; 14(4):425-9.

Whatson TS, Smart JL Social behavior of rats following pre and early postnatal undernutrition. Physiol Behav. 1978; 20(6):749-53.

Thor DH, Holloway WR. Social memory of the male laboratory rat. J Comp Physiol Psychol. 1982; 96:1000-6.

Popik P, Wolterink G, De Brabander H, Van Ree JM. Neuropeptides related to [Arg8 ] vasopressin facilitates social recognition in rats. Physiol Behav. 1991; 49(6):1031-5.

Mondadori C, Moebius HJ, Zingg M. CGP 36,742, an orally active GABAB receptor antagonist, facilitates memory in a social recognition test in rats. Behav Brain Res. 1996; 77(1-2):227-9.

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Publicado

19-09-2023

Como Citar

Consiglio da SILVA, V. ., & de Sousa ALMEIDA, S. . (2023). Desnutrição protéica no início da vida prejudica memória social em ratos adultos. Revista De Nutrição, 19(2). Recuperado de https://seer.sis.puc-campinas.edu.br/nutricao/article/view/9781

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ARTIGOS ORIGINAIS