Can maternal physical activity modulate the nutrition-induced fetal programming?
Keywords:
Motor activity, Fetal development, Phenotype, PregnancyAbstract
There is considerable evidence for the induction of different phenotypes by variations in fetal and neonatal environment. Undernutrition during this critical development period is associated with risk of metabolic disease in adult life; this biological phenomenon is termed programming. Physical activity during gestation results in maternal physiological adaptations and increased oxygen and nutrients in the fetoplacental compartment. The main goal of this work is to discuss the mechanisms of fetal programming induced by nutrition and the probable modulating effect of physical activity during gestation. Papers published between 1990 and 2008 listed in the Medline Pubmed, Lilacs and Bireme databases were used. The search keywords were: nutrition, fetal programming, gestation, physical activity, physical exercise, and metabolism. In conclusion, undernutrition can program the onset of metabolic diseases in adult life, while physical activity during gestation increases the availability of nutrients and oxygen for the fetus, thereby positively impacting fetal growth and birth weight.
References
Barker, DJ. The origins of the developmental origins theory. J Intern Med. 2007; 261(5):412-7.
Lucas A. Programming by early nutrition in man. Ciba Found Symp. 1991; 156:38-50. Discussion 50-5.
Burdge GC, Hanson MA, Slater-Jefferies JL, Lillycrop KA. Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life? Br J Nutr. 2007; 97(6):1036-46.
Angelbeck JH, DuBrul EF. The effect of neonatal testosterone on specific male and female patterns of phosphorylated cytosolic proteins in the rat preoptic-hypothalamus, cortex and amygdala. Brain Res. 1983; 264(2):277-83.
Ponnappa BC, Rubin E. Modeling alcohol’s effects on organs in animal models. Alcohol Res Health. 2000; 24(2):93-104.
Manhaes de Castro R, Barreto Medeiros JM, Mendes da Silva C, Ferreira LM, Guedes RC, Cabral Filho JE, et al. Reduction of intraspecific aggression in adult rats by neonatal treatment with a selective serotonin reuptake inhibitor. Braz J Med Biol Res. 2001; 34(1):121-4.
Mendes-da-Silva C, Souza SL, Barreto-Medeiros JM, Freitas-Silva SR, Antunes DE, Cunha AD, et al. Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats. Arq Neuropsiquiatr. 2002; 60(4):928-31.
Silva Jr. VA, Vieira AC, Pinto CF, Paula TA, Palma MB, Lins Amorim MJ, et al. Neonatal treatment with naloxone increases the population of Sertoli cells and sperm production in adult rats. Reprod Nutr Dev. 2006; 46(2):157-66.
Barker DJ, Osmond C, Golding J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989; 298(6673):564-7.
Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med. 1976; 295(7):349-53.
Barker DJ, Osmond C. Diet and coronary heart disease in England and Wales during and after the Second World War. J Epidemiol Comm Health. 1986; 40(1):37-44.
Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991; 303(6809):1019-22.
Filho MB, Rissin A. A transição nutricional no Brasil: tendências regionais e temporais. Cad Saúde Pública. 2003; 19:S181-S91.
McCance RA. Food, growth, and time. Lancet. 1962; 2(7257):671-6.
Dobbing J. The influence of early nutrition on the development and myelination of the brain. Proc R Soc Lond B Biol Sci. 1965; 159:503-9.
Costa-Cruz RR, Amancio-dos-Santos A, Guedes RC. Characterization of cortical spreading depression in adult well-nourished and malnourished rats submitted to the association of pilocarpine-induced epilepsy plus streptozotocin-induced hyperglycemia. Neurosci Letter 2006; 401(3):271-5.
Do Monte-Silva KK, Assis FL, Leal GM, Guedes RC. Nutrition-dependent influence of peripheral electrical stimulation during brain development on cortical spreading depression in weaned rats. Nutr Neurosci. 2007; 10(3-4):187-94.
Barreto-Medeiros J, Queiros-Santos A, Cabral-Filho JE, Ferreira ESWT, Leandro CG, Deiro TC, et al. Stress/aggressiveness-induced immune changes are altered in adult rats submitted to neonatal malnutrition. Neuroimmunomodulation. 2007; 14(5):229-334.
Barros KM, Manhaes-De-Castro R, Lopes-De-Souza S, Matos RJ, Deiro TC, Cabral-Filho JE, et al. A regional model (Northeastern Brazil) of induced mal-nutrition delays ontogeny of reflexes and locomotor activity in rats. Nutr Neurosci. 2006; 9(1-2):99-104.
Lopes de Souza S, Orozco-Solis R, Grit I, Manhaes de Castro R, Bolanos-Jimenez F. Perinatal protein restriction reduces the inhibitory action of serotonin on food intake. Eur J Neurosci. 2008; 27(6):1400-8.
Toscano AE, Amorim MA, Carvalho Filho EV, Aragao RS, Cabral-Filho JE, Moraes SR, et al. Do malnutrition and fluoxetine neonatal treatment program alterations in heart morphology? Life Sci. 2008; 82(21-22):1131-6.
Toscano AE, Manhaes-de-Castro R, Canon F. Effect of a low-protein diet during pregnancy on skeletal muscle mechanical properties of offspring rats. Nutrition. 2008; 24(3):270-8.
Berney DM, Desai M, Palmer DJ, Greenwald S, Brown A, Hales CN, et al. The effects of maternal protein deprivation on the fetal rat pancreas: major structural changes and their recuperation. J Pathol. 1997; 183(1):109-15.
Lesage J, Hahn D, Leonhardt M, Blondeau B, Breant B, Dupouy JP. Maternal undernutrition during late gestation-induced intrauterine growth restriction in the rat is associated with impaired placental GLUT3 expression, but does not correlate with endogenous corticosterone levels. J Endocrinol. 2002; 174(1):37-43.
Ozanne SE, Olsen GS, Hansen LL, Tingey KJ, Nave BT, Wang CL, et al. Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscle. J Endocrinol. 2003; 177(2):235-41.
Cottrell EC, Ozanne SE. Early life programming of obesity and metabolic disease. Physiol Behav. 2008; 94(1):17-28.
Cripps RL, Archer ZA, Mercer JG, Ozanne SE. Early life programming of energy balance. Biochem Soc Trans. 2007; 35(Pt 5):1203-4.
Martin-Gronert MS, Tarry-Adkins JL, Cripps RL, Chen JH, Ozanne SE. Maternal protein restriction leads to early life alterations in the expression of key molecules involved in the aging process in rat offspring. Am J Physiol Regul Integr Comp Physiol. 2008; 294(2):R494-500.
Petrik J, Reusens B, Arany E, Remacle C, Coelho C, Hoet JJ, et al. A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factorII. Endocrinology. 1999; 140(10):4861-73.
Zambrano E, Rodriguez-Gonzalez GL, Guzman C, Garcia-Becerra R, Boeck L, Diaz L, et al. A maternal low protein diet during pregnancy and lactation in the rat impairs male reproductive development. J Physiol. 2005; 563(Pt 1):275-84.
Hoppe CC, Evans RG, Moritz KM, Cullen-McEwen LA, Fitzgerald SM, Dowling J, et al. Combined prenatal and postnatal protein restriction influences adult kidney structure, function, and arterial pressure. Am J Physiol Regul Integr Comp Physiol. 2007; 292(1):R462-9.
Woodall, SM, Johnston BM, Breier BH, Gluckman PD. Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring. Pediatr Res. 1996; 40(3):438-43.
Bayol S, Jones D, Goldspink G, Stickland NC. The influence of undernutrition during gestation on skeletal muscle cellularity and on the expression of genes that control muscle growth. Br J Nutr. 2004; 91(3):331-9.
Sawaya AL, Martins PA, Grillo LP, Florencio TT. Long-term effects of early malnutrition on body weight regulation. Nutr Rev. 2004; 62(7 Pt 2): S127-33.
Sawaya AL, Dallal G, Solymos G, Sousa MH, Ventura ML, Roberts SB, et al. Obesity and malnutrition in a Shantytown population in the city of Sao Paulo, Brazil. Obes Res. 1993; 3(Suppl 2):107s-15s.
Sichieri R, Moura AS, Godoy JL, Niero N, Matsumoto FN. Nutritional status of children and occupational categories of the family in a rural community of Parana, Brazil]. Cad Saúde Pública. 1993; 9(Suppl 1):28-35.
Florencio TT, Ferreira HS, Cavalcante JC, Luciano SM, Sawaya AL. Food consumed does not account for the higher prevalence of obesity among stunted adults in a very-low-income population in the Northeast of Brazil (Maceio, Alagoas). Eur J Clin Nutr. 2003; 57(11):1437-46.
Sinclair SK, Lea RG, Rees WD, Young LE. The developmental origins of health and disease: current theories and epigenetic mechanisms. Soc Reprod Fertil Suppl. 2007; 64:425-43.
Smith FM, Garfield AS, Ward A. Regulation of growth and metabolism by imprinted genes. Cytogenet Genome Res. 2006; 113(1-4):279-91.
Clapp JF, Kim H, Burciu B, Schmidt S, Petry K, Lopez B. Continuing regular exercise during pregnancy: effect of exercise volume on fetoplacental growth. Am J Obstet Gynecol. 2002; 186(1):142-7.
Clapp JF. Influence of endurance exercise and diet on human placental development and fetal growth. Placenta. 2006; 27(6-7):527-34.
Rao S, Kanade A, Margetts BM, Yajnik CS, Lubree H, Rege S, et al. Maternal activity in relation to birth size in rural India. The Pune Maternal Nutrition Study. Eur J Clin Nutr. 2003; 57(4):531-42.
ACOG Committee Opinion. Number 267, January 2002: exercise during pregnancy and the postpartum period. Obstet Gynecol. 2002; 99(1):171-3.
Perkins CC, Pivarnik JM, Paneth N, Stein AD. Physical activity and fetal growth during pregnancy. Obstet Gynecol. 2007; 109(1):81-7.
Hatch MC, Shu XO, McLean DE, Levin B, Begg M, Reuss L, et al. Maternal exercise during pregnancy, physical fitness, and fetal growth. Am J Epidemiol. 1993; 137(10):1105-14.
Clapp JF. Effects of Diet and Exercise on Insulin Resistance during Pregnancy. Metab Syndr Relat Disord. 2006; 4(2):84-90.
Leandro CG, Manhaes de Castro R, Nascimento E, Pithon-Curi TC, Curi R. Mecanismos adaptativos do sistema imunológico em resposta ao treinamento físico. Rev Bras Med Esporte. 2007; 13(5): 343-8.
Thomas DM, Clapp JF, Shernce S. A foetal energy balance equation based on maternal exercise and diet. J R Soc Interface. 2008; 5(21):449-55.
Parnpiansil P, Jutapakdeegul N, Chentanez T, Kotchabhakdi N. Exercise during pregnancy increases hippocampal brain-derived neurotrophic factor mRNA expression and spatial learning in neonatal rat pup. Neurosci Lett. 2003; 352(1): 45-8.
Lima M, Ismail S, Ashworth A, Mies SS. Influence of heavy agricultural work during pregnancy on birth weight in North-East Brazil. Int J Epidemiol. 1999; 28(3):469-74.
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Copyright (c) 2023 Carol Góis LEANDRO, Marco Fidalgo AMORIM, Sandro Massao HIRABARA, Rui CURI, Raul MANHÃES DE CASTRO
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