Changes in nutritional status in adolescents surviving leukemia and lymphoma


  • Christy Hannah Sanini BELIN Universidade Federal do Rio Grande do Sul
  • Márjory de Camillis BUENO Universidade Federal do Rio Grande do Sul
  • Luciane Beitler DA CRUZ Universidade Federal do Rio Grande do Sul
  • Simone Geiger de Almeida SELISTRE Universidade Federal do Rio Grande do Sul
  • Estela Beatriz BEHLING Universidade Federal do Rio Grande do Sul


Adolescent, Anthropometry, Leukemia, Lymphoma, Nutritional status


To examine the changes in the nutritional status of adolescents aged 10-19 years after a minimum 12 months interval following oncological treatment for leukemias and lymphomas.
Longitudinal design quantitative study conducted at Hospital de Clínicas, Porto Alegre. Adolescents aged 10-19 years after a minimum 12 months interval following oncological treatment for leukemias and lymphomas were included. The measures of weight, height, brachial circumference, triceps skinfold thickness, arm muscle circumference and abdominal circumference were collected.
The sample comprised 50 adolescents who had survived leukemias and lymphomas. In the follow up 38% of the patients were classified as overweight according to the body mass index for their age. There was a significant increase in body mass index for age between the beginning and the end of treatment and follow up (p=0.013) in female individuals, compared to males. The results indicate a reduction in the Z-score means of height for age, with significant differences between the beginning of treatment and follow up (p=0.016); and end of treatmentand follow up (p=0.006) in patients of both genders.
The anthropometric indicators show an important frequency of excess weight and increased tricipital skinfold, as well as a significant increase of the body mass index for age and also a growth deficit among the survivors.


American Cancer Society. Cancer Facts & Figures 2017. Atlanta: Society; 2017 [cited 2019 Sept 7]. Available from:

Friestino JKO, Mendonça D, Oliveira P, Oliveira CM, Moreira DCF. Childhood cancer: incidence and spatial patterns in the city of Campinas, Brazil, 1996-2005. Salud Colect. 2018;14(1):51-63.

Noone A, Howlader N, Krapcho M, Miller D, Brest A, Yu M, et al. SEER Cancer Statistics Review 1975-2015. Bethesda: National Cancer Institute; 2018.

Hunger SP, Mullighan CG. Acute lymphoblastic leukemia in children. N Engl J Med. 2015;373(16):1541-52.

Ahmad SS, Reinius MAV, Hatcher HM, Ajithkumar TV. Anticancer chemotherapy in teenagers and young adults: managing long term side effects. BMJ. 2016;354:1-8.

Touyz LM, Cohen J, Neville KA, Wakefield CE, Garnett SP, Mallitti KA, et al. Changes in body mass index in long-term survivors of childhood acute lymphoblastic leukemia treated without cranial radiation and with reduced glucocorticoid therapy. Pediatr Blood Cancer. 2017;64(4):e26344.

Chemaitilly W, Cohen LE. Endocrine late-effects of childhood cancer and its treatments. Eur J Endocrinol. 2017;176:183-203.

Teixeira JFC, Lemos PSM, Cypriano MS, Pisani LP. The influence of antineoplastic treatment on the weight of survivors of childhood cancer. J Pediatr. 2016; 92:559-66.

Zhang FF, Parsons SK. Obesity in childhood cancer survivors: call for early weight management. Adv Nutr. 2015;6(5):611-9.

Frisancho AR. Anthropometric standards for the assessments of growth and nutritional status. Clin Nutr. 1991;10(2):131-2.

Taylor RW, Jones IE, Williams SM, Goulding A. Evaluation of waist circumference, waist-to-hip ratio, and the conicity index as screening tools for high trunk fat mass, as measured by dual energy X-ray absorptiometry, in children aged 3-19 y. Am J Clin Nutr. 2000;72:490-5.

World Health Organization. WHO Child Growth Standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. Geneva: Organization; 2006.

World Health Organization. WHO AnthroPlus for personal computers [software]. Geneva: Organization, 2009.

De Onis M, Onyango AW, Borghi A, Amani Siyam A, Nishidaa C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ. 2007;85(9):660-7.

International Business Machines Corporation. Statistical Package for Social Sciences. Version 18.0 [software]. Chicago: IBM; 2009.

Nakhaei-Moghadam M, Setoodeh A, Noori N, Rostami P, Teimouri A. Endocrine and metabolic disorders in children with cancer treatment. Zahedan J Res Med Sci. 2016;18(3):e6244.

Sousa TS, Santos LTG, Sousa P, Sousa RML, Martins ICVS, Dias LPP, et al. Indicadores antropométricos em crianças com câncer em um hospital de referência. Rev Pesq Saúde. 2016;17(3):151-3.

Wilson CL, Howell CR, Partin RE, Lu L, Kaste SC, Mulrooney DA, et al. Influence of fitness on health status among survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer. 2018;65:e27286.

Rashedy FH, Hawy A, Hefnawy SM, Mohammed MM. Assessment of obesity and hepatic late adverse effects in the egyptian survivors of pediatric acute lymphoblastic leukemia: a single center study. Mediterr J Hematol Infect Dis. 2017;9:1-7.

Elitzur S, Houri-Shtrecher R, Yackobovitz-Gavan M, Urasiński T. Growth and pubertal patterns in young survivors of childhood acute lymphoblastic leukemia. J Pediatr Endocrinol Metab. 2017;30(8):869-77.

Bayram C, Yarali N, Fettah A, Demirel F, Tavil B, Kara A, et al. Evaluation of endocrine late complications in childhood acute lymphoblastic leukemia survivors: A Report of a Single-Center Experience and Review of the Literature. Turk J Haematol. 2017;34(1):40-5.

Oliveira B, Lins M, Pedrosa F, Cabral PC, Barbosa JM. Estado nutricional de crianças e adolescentes sobreviventes de leucemia linfóide aguda, tratados em um Centro de Referência da Região Nordeste do Brasil. Rev Nutr. 2013;26(3):271-81.

Belle FN, Wenke-Zobler J, Cignacco E, Spycher BD, Ammann RA, Kuehni CE, et al. Overweight in childhood cancer patients at diagnosis and throughout therapy: a multicentre cohort study. Clin Nutr. 2019;38(2):835-41.

Antal Z, Balachandar S. Growth disturbances in childhood cancer survivors. Horm Res Paediatr. 2019;91(2):83-92.

Shah P, Jhaveri U, Idhate TB, Dhingra S, Arolkar P, Arora B. Nutritional status at presentation, comparison of assessment tools, and importance of arm anthropometry in children with cancer in India. Ind J Cancer. 2015;52(2):210-5.

Sharma AK, Metzger DL, Daymont C, Hadjiyannakis S, Rodd CJ. LMS tables for waist-circumference and waist-height ratio Z-scores in children aged 5-19 y in NHANES III: association with cardio-metabolic risks. Pediatr Res. 2015;78(6):723-9.

Ness K, Gurney JG. Adverse late effects of childhood cancer and its treatment on health and performance. Annu Rev Public Health 2007;28(1):279-302. http://10.1146/annurev.publhealth.28.021406.144049

Silva CHBA, Kuperman H, Dichtchekenian V, Damiani D, Della Manna T, Cristofani LM, et al. Growth and puberty after treatment for acute lymphoblastic leukemia. Rev Hosp Clin Fac Med S Paulo. 2004;59(2):67-70.

Ripka WL, Ulbricht L, Gewehr PM. Body composition and prediction equations using skinfold thickness for body fat percentage in Southern Brazilian adolescents. Plos One. 2017;12(9):1-13.

Soto-Vega E, Carrillo-Vicente LS, Vázquez JC, Pérez de Celis Herrero MC, Muñoz-Pérez MJ. Metabolic Changes in Children that Received Chemotherapy. J Pediatr Hematol Oncol. 2019;41(6):448-51.

Instituto Nacional de Câncer (Brasil). Consenso Nacional de Nutrição Oncológica. 2 ed. Rio de Janeiro: Instituto; 2016.

Collins L, Beaumont L, Cranston A, Savoie S, Nayiager T, Barr R. Anthropometry in long-term survivors of acute lymphoblastic leukemia in childhood and adolescence. J Adolesc Young Adult Oncol. 2017;6(2):294-8.

Kopp LM, Gastelum Z, Guerrero CH, Howe CL, Hingorani P, Hingle M. Lifestyle behavior interventions delivered using technology in childhood, adolescent, and young adult cancer survivors: a systematic review. Pediatr Blood Cancer. 2017;64:13-7.




Como Citar

Sanini BELIN, C. H. ., de Camillis BUENO, M. ., Beitler DA CRUZ, L. ., Geiger de Almeida SELISTRE, S. ., & BEHLING, E. B. . (2022). Changes in nutritional status in adolescents surviving leukemia and lymphoma. Revista De Nutrição, 33, 1–10. Recuperado de