Granulomatose de Wegener associada a tireoidite de Hashimoto: correlação anátomo-clínica em caso com necrópsia
Palabras clave:
granulomatose de Wegener, otite media aguda, tireoitite de hashimoto, necropsia, correlação anatomo-clinicaResumen
A granulomatose de Wegener é definida como uma vasculite de acometimento sistêmico, atingindo vias aéreas e rins na maioria dos casos. Sugere-se que seu mecanismo de lesão seja através de fenômenos auto-imunes, com a presença de anticorpos anti-citoplasma de neutrófilos no soro dos pacientes acometidos.
Neste relato é descrito um caso de granulomatóse de Wegener de rápida evolução para o óbito, com otite média aguda como primeira manifestação, além da coexistência de tireoidite de Hashimoto, manifestado por quadro de hipotireoidismo. A associação de outra doença auto-imune é pouco relatada e esse fato sugere a existência de algum fenômeno regulador em comum.
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