Analysis of the rational use of antihypertensive drugs in a school hospital
Keywords:
Antihypertensive agents, Comorbidity, Drug interactions, TherapeuticsAbstract
Objective
The aim of this study is to determine the antihypertensive drugs most commonly
prescribed to outpatients, assessing the rationality of prescriptions and drug interactions. It is also to determine the prevalence of comorbidities and complications associated with hypertension in the sample.
Methods
A retrospective analysis was done of 543 medical records of patients diagnosed
with hypertension who were being followed from 2000 to 2007. A questionnaire
containing age, time of diagnosis, medications used, adherence to treatment, comorbidities and adverse reactions was used to collect data.
Results
The patients aged from 20 to 95 years; 49.0% were males and 51.0% were females. Monotherapy was observed in 23.4% of the patients, 42.2% were using two drugs, 25.4% used three and 9% used four or more drugs. The most common drug was captopril (65.0%), followed by hydrochlorothiazide (44.4%) and
propranolol (28.4%). The most common associations were captopril with hydrochlorothiazide (32.7%) and captopril with propranolol (22.1%). Dyslipidemia was the most common comorbidity (44.2%). Regarding lesions of target organs (retinopathy, nephropathy or cardiopathy), only one of these complications prevailed (31.0%). The error margin for the estimated proportion was 4.0%, with a confidence interval of 95.0%.
Conclusion
The use of two drugs to control blood pressure prevailed. The most commonly
used drugs were angiotensin-converting enzyme inhibitors and their association
with diuretics or beta blockers. The availability of these drugs in the public services seems to be the main determinant for their prescription.
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References
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