Periodontal disease and diabetes mellitus: a two-way road
Keywords:
Diabetes mellitus, Risk factors, Alveolar bone lossAbstract
Objective
The objective of this study was to determine the periodontal condition of diabetic patients.
Methods
In the study, 32 type 2 uncontrolled diabetic patients (reference value of hemoglobin of 7%) and 45 nondiabetic controls (30 with periodontal disease
and 15 healthy) were evaluated. The following periodontal parameters were verified: periodontal probing depth, clinical attachment loss and missing teeth. The data were analyzed by the Mann Whitney and Student’s t test.
Results
Among diabetic patients, 17 had mild chronic periodontitis, 11 moderate and 4 severe, while in nondiabetics 15 were healthy, 13 had mild chronic periodontitis, 15 moderate and 2 severe. Diabetic patients had more missing teeth than the
nondiabetic groups (p<0.009 and p<0.0000); periodontal disease was worse than that of the healthy group (p<0.0000) but better than that of the group with
periodontal disease (p<0.0009); there was no statistically significant difference in clinical attachment loss between diabetic and nondiabetic patients with
periodontal disease (p=0.1576); they only differed from the healthy group.
Conclusion
In this study the group with diabetes had a greater number of missing teeth, which could be the result of periodontal disease. Further studies should be
conducted to clarify this association.
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References
Mealey BL, Ocampo GL. diabetes mellitus and periodontal disease. Periodontology 2000. 2007; 44(2):127-53.
Lõe H. Periodontal disease the sixth complication of diabetes mellitus. Diabetes Care. 1993; 16(1)329-34.
lacopino AM. Diabetic periodontitis: possible lipid induced defect in tissue repair through alteration of macrophage phenotype and function. Oral Dis. 1995; 1(16):214-29
Gustke CJ. Treatment of periodontitis in the diabetic patient: a criticai review. J Clin Periodontol. 1999; 26(3) 133-7.
Garcia RI, Henshaw MM, Krall EA. Relatioship between periodontal disease and systemic health. Periodontology 2000. 2001; 25(1):21-36.
Champagne CME, Buchanan W, Reddy MS, Preisser JS, Beck JD, Offenbacher S. Potential for gingival crevice fluid measures as predictors of risk for periodontal disease. Periodontology 2000. 2003; 31(1):167-80.
Khader YS, Dauod AS, EI-Qaderi SS, Alkafajei A, Batayha WQ. Periodontal status of diabetics compared with nondiabetics: a meta-analysis. J Diabetes Complications 2006; 20(1):59-68.
Oliver RC, Tervonen T. Diabetes: a risk factor for periodontitis in adults? J Periodontol. 1994; 65(5 Suppl):530-8.
Graves DT, AI-Mashat H, Liu R. Evidence that diabetes Mellitus aggravates periodontal diseases and modifies the response to an oral pathogen in animal models. Compend Contin Educ Dent. 2004; 25(7 Suppl 1):38-45
Verma S, Bhat KM. Diabetes mellitus: a modifier of periodontal disease expression. J lnt Acad Periodontol. 2004; 6(1):13-20.
Sadzeviciene R, Paipaliene P, Zekonis P, Zillinskas J. The influence of microvascular complications cause by diabetes mellitus on the inflammatory pathology of periodontal tissues. Stomatologija. 2005; 7(4): 121-4.
Liu R, Bal HS, Desta T, Krothapalli N, Alyassi M, Luan Q, et ai. Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation. J Dent Res. 2006; 85(6):510-4.
Armitage GC. Development of classification system for periodontal disease and conditions. Ann Periodontol. 1999; 4(1):1-6
Willians RC. Periodontal disease: the emergence of a new paradigm. Compend Contin Educ Dent. 1998. 19(1):4-10.
Wactawski-Wende J, Grossi SG, Trevisan M, Genco RJ, Tezal M, Dunfort RG, et ai. The role of osteopenia in oral bone loss and periodontal disease. J Periodontol. 1996; 67(10): 1076-84
Hetz-Mayfield LJ Disease progression: identification of high-risk groups and individuais for periodontitis. J Clin Periodontol. 2005; 32(Suppl 6):196-209.
Faria-Almeida R, Navarro A, Bascones A. Clinicai and metabolic changes after conventional treatment of type 2 diabetic patients with chronic periodontitis. J Periodontal. 2006; 77(4):591-8
Cohen DW, Rose LF. The periodontal-medic risk relationship. Compend Contin Educ Dent. 1998; 19(1):11-24.
Grossi SG, Genco RJ. Periodontal disease and diabetes mellitus: a two way relationship. Ann Periodontol. 1998; 3(1):51-61.
Taylor GW. Bidirectional interrelationships between diabetes and periodontal diseases an epidemiologic perspective. Ann Periodontol. 2001; 6(1):99-112.
Mealey BL, Oates TW. diabetes mellitus and periodontal diseases. J Periodontol. 2006; 77(8) 1289-303.
Grupo Interdisciplinar de Padronização da Hemo globina Glicada - A1C. Atualização sobre hemoglo bina glicada (a1e) para avaliação do controle glicêmico e para o diagnóstico do diabetes: aspectos clínicos e laboratoriais. 3ª ed. 2009 [acesso 201O fev. 20] Disponível em: <http://www.sbem.org.br/media/fotos/ posicionamento_oficial_2009_A 1C.pdf>.
The American Academy of Periodontology. Ann Periodontol. 1999; 4(1):1-6.
Lyra R, Oliveira M, Lins D, Cavalcanti N. Prevenção em diabetes Mellitus tipo 2. Arq Bras Endocrinol Metab. 2006; 50(2):239-49
Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005; 366:1809-20.
Doxey DL, Cutler CW, lacopino AM. diabetes prevents periodontitis-induced increases in gingival platelet derived growth factor-B and interleukin-1 in rat model. J Periodontol. 1998; 69(2):113-9
Bulut U, Develioglu H, Taner IL, Berker E. lnterleukin-1 beta leveis in gingival crevicular fluid in type2 diabetes Melittus and adult periodontitis J Oral Sei. 2001; 43(3):171-7.
Engebretson SP, Hey-Hadavi J, Ehrhardt FJ, Hsu D, Celenti RS, Grbic JT, et ai. Gingival crevicular fluid leveis of interleukin-1 and glycemic contrai in patients with chronic periodontitis and Type 2 diabetes. J Periodontol. 2004; 75(9):1203-8.
Cutler CW, Machen RL, Jotwani R, lacopino A. Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia. J Periodontol. 1999; 70(11):1313-21.