Changes in laboratory parameters in patients with COVID-19

a systematic review

Authors

DOI:

https://doi.org/10.24220/2318-0897v31e2022a5379

Keywords:

Biomarkers, Covid-19, Laboratory diagnosis

Abstract

The objective of this study was to identify and gather the main findings available at the beginning of the pandemic, regarding laboratory alterations of hospitalized patients with COVID-19 and to discuss the predominance of these alterations in the severity of the course of the disease. This is a systematic literature review, restricted to publications until April 2020, using the Lilacs and Pubmed databases. A total of 381 publications were found in the consulted databases and of these, 17 publications were eligible for analysis according to the inclusion and exclusion criteria. Laboratory parameters such as the reduction of lymphocytes and the elevation of D-dimers, lactate dehydrogenase and C-reactive protein appear to be linked to SARS-CoV-2 infection and may serve as prognostic indicators of the disease. Lymphocytopenia and increased D-dimers are markers related to disease worsening and unfavorable outcomes such as death.

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Author Biographies

Matheus Coimbra Sebotaio, Pontifícia Universidade Católica do Rio Grande do Sul, Hospital São Lucas, Laboratório Clínico.

Farmacêutico pela Universidade Federal do Rio Grande do Sul, Residente no Programa Apoio Diagnóstico Terapêutico do Hospital São Lucas da PUCRS, atualmente trabalha com ênfase em bioquímica e hematologia no Laboratório Clínico do HSL e como parte do corpo assistencial com ênfase em intensivismo e cuidados paliativos.

Kathleen Asturian, Pontifícia Universidade Católica do Rio Grande do Sul, Hospital São Lucas, Laboratório Clínico

Farmacêutica pela Universidade Federal do Rio Grande do Sul, Residente no Programa Apoio Diagnóstico Terapêutico do Hospital São Lucas da PUCRS, atualmente trabalha com ênfase em imunologia e microbiologia no Laboratório Clínico do HSL e como parte do corpo assistencial com ênfase em intensivismo.

Olavo José Vicente Neto, Pontifícia Universidade Católica do Rio Grande do Sul, Hospital São Lucas, Laboratório Clínico.

Farmacêutico pela Fundação Educacional Serra dos Órgãos/RJ, Especialista em Urgência e Trauma e Mestre em Toxicologia pelo Centro Universitário Feevale/RS. Atualmente é Farmacêutico Clínico do Hospital São Lucas.

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Published

2022-10-17

How to Cite

Sebotaio, M. C., Asturian, K., & Neto, O. J. V. (2022). Changes in laboratory parameters in patients with COVID-19: a systematic review. Revista De Ciências Médicas, 31. https://doi.org/10.24220/2318-0897v31e2022a5379