Uso de metformina em mulheres obesas com Síndrome do Ovário Policístico

Authors

  • Lincoln Rodrigues Augusto de FREITAS Faculdade de Minas http://orcid.org/0000-0002-3417-1057
  • Jerffesson Gean SANTOS Faculdade de Minas
  • Markus Thulio Alves GUIMARÃES Faculdade de Minas
  • José Helvécio Kalil de SOUZA Faculdade de Minas

DOI:

https://doi.org/10.24220/2318-0897v25n2a3613

Keywords:

Hiperandrogenismo. Metformina. Obesidade. Síndrome do ovário policístico.

Abstract

A Síndrome do Ovário Policístico caracteriza-se como uma alteração anatômica e morfológica dos ovários que acarreta hiperandrogenismo, ciclos menstruais irregulares, redução da fertilidade e múltiplos cistos ovarianos, principalmente em mulheres obesas durante a menacme. Como o aumento da resistência à insulina e a hiperinsulinemia estão frequentemente presentes, a metformina começou a ser preconizada na clínica como uma forma de tratamento da Síndrome do Ovário Policístico. Dessa forma, o presente estudo tem como objetivo realizar uma revisão de literatura sobre o uso de metformina em mulheres obesas com a síndrome citada. Para tanto, foi realizada uma pesquisa nas bases de dados PubMed/MedLine, Portal CAPES, SciELO, Cochrane e Google Acadêmico no período de fevereiro a maio de 2016. Os artigos foram identificados pelos seguintes descritores: "polycystic ovary syndrome", "metformin", "hyperandrogenism and obesity". Não houve restrição quanto à data de publicação dos artigos e idioma. Uma ampla utilização da metformina é identificável no tratamento da Síndrome do Ovário Policístico, porém ainda existe discordância sobre sua efetividade de forma isolada. Estudos utilizando monoterapia de metformina identificaram auxílio na redução de peso e melhora nas taxas de gravidez. Nos estudos utilizando terapia combinada, ocorreu melhora significativa nas taxas de ovulação e gravidez. Por fim, nos trabalhos que compararam o uso da metformina com modificação do estilo de vida, foi observado que a redução do peso teve impacto mais significativo nas taxas de ovulação e gravidez. Assim, apesar deste fármaco melhorar sintomas da síndrome do ovário policístico, o fator que mais colabora para ciclos menstruais regulares e melhoraria nas taxas de ovulação/gravidez é a redução do peso.

 

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Author Biographies

Lincoln Rodrigues Augusto de FREITAS, Faculdade de Minas

1 Faculdade de Minas, Escola de Medicina, Núcleo de Saúde da Mulher. Av. Cristiano Machado, 12001, Vila Clóris, 31744-007, Belo
Horizonte, MG, Brasil. 

Jerffesson Gean SANTOS, Faculdade de Minas

1 Faculdade de Minas, Escola de Medicina, Núcleo de Saúde da Mulher. Av. Cristiano Machado, 12001, Vila Clóris, 31744-007, Belo
Horizonte, MG, Brasil. 

Markus Thulio Alves GUIMARÃES, Faculdade de Minas

1 Faculdade de Minas, Escola de Medicina, Núcleo de Saúde da Mulher. Av. Cristiano Machado, 12001, Vila Clóris, 31744-007, Belo
Horizonte, MG, Brasil. 

José Helvécio Kalil de SOUZA, Faculdade de Minas

1 Faculdade de Minas, Escola de Medicina, Núcleo de Saúde da Mulher. Av. Cristiano Machado, 12001, Vila Clóris, 31744-007, Belo
Horizonte, MG, Brasil. Correspondência para/Correspondence to: JHK SOUZA. E-mail: <jhkalil@gmail.com>.

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Published

2017-04-10

How to Cite

FREITAS, L. R. A. de, SANTOS, J. G., GUIMARÃES, M. T. A., & SOUZA, J. H. K. de. (2017). Uso de metformina em mulheres obesas com Síndrome do Ovário Policístico. Revista De Ciências Médicas, 25(2), 87–97. https://doi.org/10.24220/2318-0897v25n2a3613