Síndrome de Gorlin Goltz e suas implicações odontológicas
DOI:
https://doi.org/10.24220/2318-0897v24n3a3312Keywords:
Carcinoma. Síndrome do nevo basocelular. Tumores odontogênicos.Abstract
Este estudo tem por objetivo realizar uma revisão de literatura sobre a Síndrome de Gorlin Goltz com foco em sua principal complicação odontológica, o Tumor Odontogênico Ceratocístico. A busca foi feita nas bases de dados Pubmed, Science Direct e Wiley Online Library. Buscou-se artigos clínicos e pesquisas publicados no período de 2010 a 2015 que estivessem relacionados à Síndrome de Gorlin Goltz e ao Tumor Odontogênico Ceratocístico ou que abordassem a inter-relação entre ambos. Além disso, também foram selecionados estudos os quais abrangessem a importância do cirurgião dentista no diagnóstico precoce da morbidade de base a partir de achados do referido tumor. Somente as pesquisas em língua estrangeira, preferencialmente em inglês, foram incluídas nesta revisão. Diante das alterações fisiopatológicas que a Síndrome de Gorlin Goltz causa, compreende-se a relevância do acompanhamento desses pacientes por uma equipe multiprofissional, especialmente pelo cirurgião dentista, uma vez que este é o responsável direto pelo diagnóstico e tratamento da principal morbidade associada à síndrome.
Palavras-chave: Carcinoma. Síndrome do nevo basocelular. Tumores odontogênicos.
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References
Rodríguez RG, Cossìo PI, Parejo PR, Carranza ET, García
AGP, Castro DS. Síndrome de Gorlin-Goltz: manejo
del carcinoma basocelular facial. Rev Esp Cir Oral
Maxilofac. 2013; 35(1):23-30.
Casaroto AR, Loures DCNR, Moreschi E, Veltrini VC,
Trento CL, Gottardo VD, et al. Early diagnosis of Gorlin-
Goltz syndrome: case report. Head Face Med. 2011;
:2.
Chandran S, Marudhamuthu k, Riaz R, Balasubramaniam
S. Odontogenic keratocysts in Gorlin-Goltz
Syndrome: A case report. J Int Oral Health. 2015;
(Suppl. 1):76-9
Mazzuoccolo LD, Martinez MF, Muchnik C, Azurmendi
P, Stengel F. Síndrome de carcinoma basocelular
nevoide con agenesia de cuerpo calloso, mutación
en PTCH1 y ausencia de carcinoma basocelular. Rev
Med (Buenos Aires). 2014; 74(4):307-10.
Sasaki R, Miyashita T, Matsumoto N, Fujii K, Saito K,
Ando T. Multiple keratocystic odontogenic tumors
associated with nevoid basal cell carcinoma syndrome
having distinct PTCH1 mutations: A case report. Oral
Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;
(2):41-6.
Borgonovo AE, Lascia SD, Grossi G, Maiorana C. Twostage
treatment protocol of keratocystic odontogenic
tumour in young patients with Gorlin-Goltz
syndrome: Marsupialization and later enucleation
with peripheral ostectomy. A 5-year-follow-up
experience. Int J Pediatr Otolaryng. 2011;
(12):1565-71.
Gupta SR, Jaetli V, Mohanty S, Shama R, Gupta A.
Nevoid basal cell carcinoma syndrome in Indian
patients: A clinical and radiological study of 6 cases
and review of literature. Oral Surg Oral Med Oral
Pathol Oral Radiol. 2012; 113(1):99-110.
Yamamoto T, Ichioka H, Yamamoto K, Kanamura N,
Sumitomo S, Shikimori M, et al. Nevoid basal cell
carcinoma syndrome: Clinical features and
implications of development of basal cell carcinoma
in skin and keratocystic odontogenic tumor in jaw
and their gene expressions. Asian J Oral Maxillofac
Surg. 2011; 23(3):105-12.
Jeyaraj P, Naresh N, Srinivas V. Case report on multiple
keratocystic odontogenic tumors of jaws: Comparison
of a non-syndromic case versus a case of Gorlin Goltz
Syndrome. J Oral Maxillofac Surg Med Pathol. 2014;
(4):569-575.
Mojsa I, Stypulkowska J, Kaczmarzyk T, Okon K, Zaleska
M. Treatment of a patient with large keratocystic
odontogenic tumour in the mandible: Case report
with literature review. Oral Surg. 2012; 5(1):1-6.
Kalia V, Kaushal N, Kalra G. The syndromic multiple
odontogenic keratocyst in siblings: A familial study.
Ann Maxillofac Surg. 2011; 1(1):77-82.
Kargahi N, Kalantari M. non-syndromic multiple
odontogenic keratocyst: A case Report. J Dent (Shiraz).
; 14(3):151-4.
Almeida Júnior P, Cardoso LC, Garcia Júnior IR, Magro
Filho O, Luvizuto ER, Felipini RC. Conservative
approach to the treatment of keratocystic odontogenic
tumor. J Dent Child. 2010; 77(3):135-9.
Santos JN, Carneiro Junior B, Alves Malaquias PDTI,
Henriques, ACG, Cury PR, Rebello IMCR. Keratocystic
odontogenic tumour arising as a periapical lesion.
Int Endod J. 2014; 47(8):802-9.
Siles MS, Alonso FC, Jornet PL, Sanchez NS.
Keratocystic odontogenic tumor: A case report and
review of the literature. N Y State Dent J.2013;
(2):44-7.
Shimada Y, Morita K, Kabasawa Y, Taguchi T, Omura
k. Clinical manifestations and treatment for
keratocystic odontogenic tumors associated with
nevoid basal cell carcinoma syndrome: A study in 25
Japanese patients. J Oral Pathol Med. 2013;
(3):275-80.
Leonardi R, Matthews JB, Caltabiano R, Greco M,
Lombardo C, Loreto C, et al. MMP-13 expression in
keratocyst odontogenic tumour associated with
NBCCS and sporadic keratocysts. Oral Dis. 2010;
(8):795-800.
Kadlub N, Gatibelza ME, El Houmami N, Coulomb-
Lhermine A, Descroix V, Ruhin-Poncet B, et al. Tumeurs
ke´ratokystiques odontoge‘nes de l’enfant et
syndrome de Gorlin. Comment expliquer les re´cidives
et l’agressivite´ des le´sions? Rev Stomatol Chir
Maxillofac Chir Orale. 2012; 113(3):148-54.
Pierro VS. Clinical and oral findings in an Afro-
Brazilian family with Gorlin-Goltz syndrome: Case
series and literature review. Spec Care Dentist. 2015;
(1):43-50.
Sung-Il Y, Young-In P, So-Young C, Jin-Wook K, Chin-
Soo K. A retrospective study of 220 cases of
keratocystic odontogenic tumor (KCOT) in 181
patients. Asian J Oral Maxillofac Surg. 2011;
(3):117-21.
Titinchi F, Nortje CJ. Keratocystic odontogenic tumor:
A recurrence analysis of clinical and radiographic
parameters. Oral Surg Oral Med O, 2012; 114(1):136-
McDonald DS, Li TK, Goto TK. A consecutive case series
of nevoid basal cell carcinoma syndrome affecting
the Hong Kong Chinese. Oral Surg Oral Med Oral
Pathol Oral Radiol. 2015; 120(3):408-15.
Malcic AI, Breen L, Josic D, Krmec SJ, Dzombeta T,
Matijevic J, et al. Proteomics profiling of keratocystic
odontogenic tumours reveals AIDA as novel
biomarker candidate. J Oral Pathol Med. 2015;
(5):367-77.
Therkildsen NM, Andersen K, Blomlöf J. Diagnostic
sensitivity and specificity in a retrospective clinical,
radiographic and histopathological study of 166
cystic jawlesions. Oral Surg.2014; 7(1):33-8.
Kulkarni GH, Khaji SI, Metkari S, Harish S, Kulkarni
HS, Kulkarni R. Multiple keratocysts of the mandible
in association with Gorlin-Goltz syndrome: A rare case
report. Contemp Clin Dent. 2014; 5(3):419-21.
Chander M, Mishra M, Gaur A, Fatima T, Mondal S,
Dhar S. Gorlin Goltz syndrome: A case report. Int J Sci
Res. 2015; 2(1):20-24.
