Therapeutic monitoring of anticonvulsant drugs
Keywords:
anticonvulsants, chromatography, gas, liquidAbstract
The therapeutic monitoring of drugs in plasma has been an important instrument to assure a therapy with the maximum efficacy and the minimum toxic effects, in an individual manner, since therapeutic and toxic effects are better related to plasmatic concentration than to the administered dose. Analytical techniques frequently used for the determination of anticonvulsant drugs are
gas-liquid chromatography (GLC), high performance liquid chromatography (HPLC) and immunologic techniques (polarisation fluoroimmuno assay - PFIA). Primidone, phenobarbital, phenytoin, carbamazepine and 10,11 carbamazepine-epoxide were determined in freeze-dried samples of plasma and GLC, HPLC and PFIA techniques were used The results were compared according to data reported the Health Control External Quality Assessment Scheme in Cardiff.
Downloads
References
CRETELLA, Y.A. Controle terapêutico de fenobarbital, fenitoina e carbamazepina. Revista Brasileira de Toxicologia, São Paulo, v. 3, n.2, p.49, 1990.
GOODMAN, L.s., GILMAN, A.G. The pharmacological basis Q/therapeutics. New York McMillan, 1986. 1200p
SPINELLI, E., SILVA, O.A. Imunoensaio de fluorescência polarizada e sua aplicação na detecção de usuários de cannabis. Revista Brasileira de Toxicologia, São Paulo, v. 7, n. 1/2, p. 37-43, 1994.
WILSON,J.F., TSANACLIS, L.M., PERRETT, J.E., WILLIAMS, J., WICKS, J.F.c., RICHENS, A. Performance of techniques for measurement of therapeutic drugs in serum. A comparison based on external quality assessment data. Therapeutic Drug Monitoring, New York, v. 14, n.2, p.98-105, 1992.
