Breast and ovary primary carcinoma in the same patient
report of five cases
Keywords:
carcinoma, breast neoplasms, ovarian neoplasms, diagnosis, treatmentAbstract
Of patients with primary tumors of ovary and breast, selected amongst 287 women with ovarian cancer attended at the Centro de Atenção Integral à Saúde da Mulher, Universidade Estadual de Campinas from 1986 and 1997, are related. Median age at first diagnosis was 52 years old (minimum of 44 and maximum of 64 years). Four (case 2, 3, 4 and 5) among the five breast tumors were ductal carcinoma and all presented a grade III of diferentiation. Regarding ovarian neoplasm, three presented papilliferous adenocarcinoma (case l, 3 and 4) and the case 2 presented an endometrium adenocarcinoma. The case 5 presented an undifferentiated adenocarcinoma, but limited to one ovary and with lymphonodal extention. All ovarian neoplasm were diagnosed in advanced stage. Two cases were synchronous and three cases were metachronous. In two metachronous cases breast cancer was diagnosed firstly and in the other case the first diagnosed tumor was the ovarian carcinoma. The median interval between the first and the second tumor in these three cases was 38 months. Although rare, primary breast and ovarian cancer can coexist in the same woman and physicians need to be aware of the presence of adnexial mass in women with breast cancer and breast node in women with ovarian neoplasm. Treatment must be complete for both neoplasms.
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References
CURTIN, J.P., BARAKAT, R.R., HOSKINS, W.J. Ovarian disease in women with breast cancer. Obstet Gynecol, New York, v.84, n.3, p. 449452, 1994.
DOBERNECK, R.c., GARCIA, J.E. Primary breast cancer in patients with previous endometrial or ovarian cancer. J Surg Oncol, New York, v. 37, n.2, p. 100-103, 1988.
EASTON, D.F., FORD, D., BISHOP, D.T. Breast cancer linkage consortium. Breast and ovarian cancer incidence in BRCAl-mutation carries. Am J Hum Genet, Chicago, v.56, n.1, p.265-271, 1995.
FISHMAN, A. et al. A second primary malignancy in a cohort of patients with epithelial ovarian cancer: characteristics of diagnosis. Eur J Gynaecol Oncol, Padua, v.19, n.3, p.280-283, 1998.
LETHAI, N. et al. Cancer of the ovary after cancer of the breast: 45cases. J Gynecol Obstet Biol Reprod, Paris, v.20, n.8, p. 1043-1048, 1991.
LIVSHITS, M.A., DYMARSKII, L.L. U. Differential diagnosis of primary and metastatic ovarian tumors in patients treated for breast cancer. Vopr Onkol, Leningrad, v.31, n. 3, p. 63-68, 1985.
NEWHAUSEN, S. et al. Recurrent BRCA2 mutation in Ashkenazi Jewish women affected by breast cancer. NatGenet, New York, v. 13, n. l , p. 126-128, 1996.
PRIOR, P., WATERHOUSE, J.Å. Multiple primary cancers of the breast and ovary. Br J Cancer, London, v.44, n.5, p.628-636, 1981.
ROBINSON, E. et al. Clinical characteristics of patients with a second primary tumor in the endometrium or ovary. Eur J Gynaecol Oncol, Padua, v. 16, n.3, p.195-198, 1995.
SCHILDKRAUT, J.M., THOMPSON, W.D. Relationship of epithelial ovarian cancer to other malignancies within families. Genet Epidemiol, New York, v. 5, n. 5, p. 355-367, 1988.
SCHILDKRAUT, J.M., RISCH, N., THOMPSON, W.D. Evaluating genetic association among ovarian, breast, and endometrial cancer: evidence for a breast/ovarian cancer relationship. Am J Hum Genet, Chicago, v.45, n.4, p.521-529, 1989.
SHAH, S. et al. Assessment of relative risk of second primary tumors after ovarian cancer and of the usefulness of double primary cases as a source of material for genetic studies with a cancer registry. Cancer, Philadelphia, v. 72, n. 3, p. 819-827, 1993.
SURIS-SWARTZ, P.J. et al. Age at diagnosis and multiple primary cancers ofthe breast and ovary. Breast Cancer Res Treat, The Hagve, v.41, n. 1, p.21-29, 1996.
