NEW COMMERCIAL FORMULATIONS OF AMPHOTERICIN B
Keywords:
amphotericin B, eye infections, parasitic, mycosesAbstract
Amphotericin B remains the gold standard for treatment of invasive fungai infections. To improve this drug's efficacy and reduce its acute and chronic toxicities, severa! lipid formulations of the drug have been developed: liposomal amphotericin 8 (AmBisome®), amphotericin 8 !ipid complex (ABLC,Abelcet®) and amphotericin 8 col/oidal dispersion (ABCD, Amphocil®). These new formulations are effective in various systemic fungai infections including candidiasis, invasive aspergilosis, mucormycosis, cryptococcosis, fusariosis and are a/so effective in treating leishmaniasis. The three formulations present little renal toxicity and are safer than conventional amphotericin 8 in this respect. Few data are available comparing these lipid formulations. Large-sca/e clinica/ triais may clarify their re!ative efficacy against various forms of fungai infections. The present bibliographical review analyzes the available data, compares the three lipid formulations to each other, and discusses the treatment's cost and benefit to the patients.
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