BREAST CANCER IN MEN: EPIDEMIOLOGICAL, CLINICAL ANO THERAPEUTIC ASPECTS
Keywords:
ductal, breast, carcinoma, breast neoplasms, men's healthAbstract
Objective
To assess the epidemio/ogic, clinica/ and therapeutic aspects of breast cancer in men.
Methods
ln the municipality of Campinas, São Paulo, Brazil, a descriptive, retrospective study was conducted to review 25 cases of ma/e breast cancer; diagnosed, from 1992 to 2005, at the following institutions: General Hospital and Maternity Celso Pierro of the Pontifical Catholic University of Campinas, the Women's Integral Healthcare Center of the State University of São Paulo and the Laboratory of Anatomic Pathology at the Campinas Maternity Hospital. The study evaluated the patients' clinica/, personal and family histories, as well as the anatomo-pathologic diagnosis, the, treatment performed and the clinica! course of each case. Because it regards a rare disease, with a sma/1 number of cases, the data of this study was not submitted to statistica/ analysis; instead, ali data was presented through frequencies and means of ali the variab/es studied.
Results
Three cases of patients under 40 years of age; seven cases, aged between 41 and 60 years; and 15 cases of patients over 60 years were evaluated. Twenty-two patients were white, one was black and two were mulatto. Regarding the time since the first symptoms appeared, until the time of diagnosis, seven patients were diagnosed within six months, six patients were diagnosed from seven to 12 months /ater, five patients were diagnosed during the second year of symptoms; and seven patients were diagnosed more than two years after the first symptoms. The most common symptom was a breast lump, histologica/ly confirmed as invasive ducta/ carcinoma in 23 cases. Mastectomy was performed in 24 cases.
Conc/usion
Regarding these cases of breast cancer in men, the study found that the diagnosis took a longer time to be made, than the time taken to diagnose breast cancer in women, according to what is mentioned in the related literature. Thus, due to the delay in diagnosis after the first complaints, more than ha/f of the patients evaluated in this study were diagnosed at an advanced stage of the disease.
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References
Giordano SH, Buzdar AU, Hortobagy GN. Breast cancer in men. Ann lntern Med. 2002; 1(8)678-87.
Philoptts LE, Smith RA. Screening for breast cancer. Sem (in) Roentgenology. 2003; 38(1):19-33.
O'Malley CD, Prehn AW, Shema SJ, Glaser SL. Racial/ ethnic differences in survival rates in a population-based series of men with breast carcinoma. Cancer. 2002; 94(11):2836-43.
Instituto Nacional do Câncer. Estimativa 2005: inci dência de câncer no Brasil 2005. Disponível em: http:// www.gov.br/estimativas/2005
Smolin Y, Massie MJ. Male breast cancer: a review of the literature and a case report. Psychosomatics. 2002; 43(4):326-30.
Gibson TN, Brady-West D, Willians E, Walters J. Male breast cancer: An analysis of four cases and review of the literature. West lndian Med J. 2001; 50(2):165-8.
Hali F, Chiheb S, EI Quazzani T, Lakhdar H. Male breast cancer in Morocco. Ann Dermatol Vereneol. 2002; 129(5 pt 1):699-702
EI Omari-Alaui H, Lahdiri 1, Neijar 1, Hadadi K, Ahyoud F, Hachi H. et ai. Male breast cancer: a report of 71 cases. Cancer Radiother. 2002; 6(6):349-51.
Giordano SH. A review of the diagnosis and management of male breast cancer. Oncologist. 2005; 10(7):471-9.
O. Luzzatto R, Martins RM. Câncer de mama em um homem com 18 anos: relato de um caso. AMRIGS. 1983; 27(4):482-7.
Heinig J, Jackish C, Rody A, Koch O, Buechter D, Schneider HP. Clinicai management of breast cancer in males: A report of four cases. Eur J Obstet Gynecol Reprod Biol. 2002; 102(1):67-73.
Westenend PJ, Jobse C. Evaluation of fine-needle aspiration cytology of breast masses in males. Cancer. 2002; 96(2):1O1-4.
Siddiqui MT, Zakowski MF, Ashfaq R, Ali SZ. Breast masses in males: Multi-institutional experience on fine-needle aspiration. Diagn Cytopathol. 2002; 26(2):87-91.
Hill A, Yagmunr Y, Tran KN, Bolton JS, Robson M, Borgen PI. Localized male breast carcinoma and family history: an analysis of 142 patients. Cancer. 1999; 86(5):821-5.
Scot-Conner CE, Jochinsem PR, Menck HR, Winchester DJ. An analysis of male and female breast cancer treatment and survival among demographically identical pairs of patients. Surgery. 1999; 126(4): 775-80.
Mourão NM, Logullo AF, Nonogaki S, Brentani RR, Brentani MM. Expression of c-erbB-2, p53 and c-myc proteins in male breast carcinoma. Braz J Med Biai Res. 2001; 34(7):887-94.
Muir D, Kanthan SC. Male versus female breast cancers A population- based comparative immunohistochemical Analysis. Arch Pathol Lab Med. 2003; 127(1):36-41.
Maranhão N, Costa 1, Nascimento RCG. Anorma lidades radiológicas da mama masculina. Rev Imagem. 1998; 20:7-13.
Yang WT, Whitman GJ, Yuen EH, Tse GM, Stelling CB. Sonographic features of primary breast cancer in men. AJR Am J Roentgenol. 2001; 176(2):413-6.
Simmons RM. Male ductal carcinoma in situ presenting as bloody nipple discharge: a case report and literature review. Breast J. 2002; 8(2):112-4.
Brenner RJ, Weitzel JN, Hansen N, Boasberg P. Screening-detected breast cancer in a man with BRCA 2 mutation. Radiology. 2004; 230(2):553-5.