Ultravio let radiation and carcinogenesis
Keywords:
Carcinogens, environmental, Skin neoplasms, Solar radiationAbstract
The basic causative factor of skin cancer is sunlight and fair-skinned people are more
prone to develop this neoplasm. Repeated solar exposure is the major environmental insult that contributes to clinical and histological epidermal changes. Chronic exposure to sunlight results in skin damages with the onset of wrinkles, harshness, dryness,
telangiectases, irregular pigmentation and a variety of lesions that can be benign, precancerous or malignant. The carcinogenic process consists of multiple factors, The
purpose of this paper was to review these factors and reinforce the importance of
preventing skin cancer by using sunscreens and avoiding prolonged exposure to ultraviolet light.
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References
Diepgen TL, Mahler V The epidemiology of skin cancer. Br J Dermatol Suppl. 2002; 146(61):1-6, Quinn AG. Ultraviolet radiation and skin carctnogenesis. Br J Hosp Med. 1997; 58(6):261-4.
Bãckvall H, Wolf O, Hermelin H, Weitzberg E, Pontén F. The density of epidermal p53 clones is higher adjacent to squamous cell carcinoma in comparison with basal cell carcinoma. Br J Dermatol. 2004; 150(2):259-66.
Brasil. Ministério da Saúde. Instituto Nacional do Câncer. Estimativas de incidência e mortalidade de câncer no Brasil [acesso 2006 abr 1]. Disponível em: http://www.inca.gov.br/estimativas/2006/tbregioes_consolidado.asp
Hildesheim J, Awwad RT, Fornace, AJJ. p38 mitogen activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses. J Investig Dermatol Symp Proc. 2004; 122(2):497-502.
Wulf HC, Sandby-Moller J, Kobayasi T, Gniadecki R. Skin aging and natural photoprotection. Micron 2004; 35(3):185-91.
Thornhil MH. The sun, the ozone layer and the skin: the role of ultraviolet light in lip and skin cancer. Dental Update. 1993; 20(6):236-40.
Nora AB. Panarotto D. Lovatto L, Boniatti MM Frequência de aconselhamento para prevenção de câncer da pele entre as diversas especialidades médicas em Caxias do Sul. An Bras Derrnatol. 2004; 79(1):45-51.
Rawashdeh MA. Matalka l. Basal cell carcinoma of the maxillofacial region: site distribution and incidence rates in Arab/Jordanians, 1991 to 2000. J Oral Maxillofac Surg. 2004; 62(2):145-49.
Carvalho CA, Cunha ME, Giugliani R, Bakos L, Ashton-Prolla P Melanoma hereditário: prevalência de fatores de risco em um grupo de pacientes no Sul do Brasil An Bras Dermatol. 2004; 79(1):53-60.
Neville BW, Damm DD, Allen CM. Doenças dermatológicas. In: Neville BW, Damm DD, Alien CM, Bouquot JE, editores. Patologia oral e maxilofacial. Rio de Janeiro: Guanabara-Koogan; 1998. p.528-78.
Fernandes NC. Cuzzi T. Calmon R, Silva CSC. Maceira JP. Melanoma cutâneo: estudo prospectivo de 65 casos. An Bras Dermatol. 2005; 80(1):25-34.
Katalinic A, Kunze U, Schãfer T. Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumor stages and localization (epidemiology of skin cancer). Br J Dermatol. 2003; 149(6):1200-6.
Rhee JS, Loberiza FR. Matthews BA, Neuburg M, Smith TL, Burzynski M. Quality of life assessment in nonmelanoma cervicofacial skin cancer. Laryngoscope. 2003; 113(2):215-20.
Rinker MH, Fenske NA, Scalf LA, Glass LF. Histologic variants of squamous cell carcinoma of the skin Cancer Control. 2001 ; 8(4):354-63.
Lohmann CM, Solomon AR. Clinicopathologic variants of cutaneous squamous cell carcinoma. Adv Anat Pathol. 2001; 8(1):27-36.
Graells J. The risk and risk factors of a second nonmelanoma skin cancer: a study in a Mediterranean population. J Eur Acad Dermatol Venereol. 2004; 18(2): 142-7.
Vries E, van de Poll-Franse LV, Louwman WJ, de Gruijl FR, Coebergh JW. Predictions of skin cancer incidence in the Netherlands up to 2015. Br J Dermatol. 2005; 152(3):48 1-8.
Salgado JM. Nutrição na terceira Idade. In: Brunetti R, Montenegro LF, editores. Odontogeriatria-noções de interesse clínico. São Paulo: Artes Médicas; 2002 p. 61 -70.
Benemburg M, Plettenberg H, Krutmann J Photoaging of human skin . Photodermathol Photoimmunol Photomed. 2000; 16(6):239-44.
Rudolph R, Zelac D. Squamous cell carcinoma of the skin. Plast Reconstr Surg. 2004; 114(6):82-94.
Berking C, Takemoto R, Binder RL, Hartman SM, Ruiter DJ, Gallagher PM, et al. Photocarcinogenese in human adult skin grafts. Carcinogenesis. 2002; 23(1):181-7.
Mitchell DL, Greinert R, Gruijl FR, Guikers KLH, Breitbart EW, Byrom M. et al. Effects of chronic lowdose ultraviolet B radiation on DNA damage and repair in mouse skin. Cancer Res. 1999; 59(1 5):2875-84.
Wikonkal NM. Brash DE. Ultravtolet radiation induced signature mutations in photocarcinogenesis. J Investig Dermatol Symp Proc. 1999 ; 4(1):6-10.
Brasileiro Filho G, Guimarães RC, Bogliolo L Distúrbios do crescimento e da diferenciação celular. In: Brasileiro Filho G, editor, Patologia geral. Rio de Janeiro: Guanabara-Koogan; 1998. p.148-92.
Lane DP Cancer. p53, guardian of the genome. Nature 1992; 358(6381): 15-6.
Maltzrnan W, Czyzyk L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol Cel Biol. 1984; 4(9):1689-94.
Clydesdale GJ, Dandie GW. Muller HK. Ultraviolet light induced injury: immunological and inftammatory effects. Immunol Cell Bioi. 2001; 79(6):547-68.
Hildesheim J. Bulavin DV, Anver MR. Alvord WG. Hollander C, Vardanian L, et al. Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via M APK and p53. Cancer Res. 2002; 62(24):7305-15.
Juchem PP, Hochberg J, WÉnogron A, Ardenghy M, English R, Riscos à saúde da radiação ultravioleta Rev Bras Cir Plast [periódico online]; 1998 [acesso 2005 abr 14]; 13(2). Disponível em: http.cirurgiaplastica.org.br/revista/indice/vo113_n2/ultravioleta
Souza SRP. Fischer FM, Souza JMP. Bronzeamento e risco de melanoma cutâneo: revisão da literatura. Rev Saúde Pública. 2004; 38(4):588-98.
