Síndrome de Gorlin Goltz e suas implicações odontológicas

Autores

  • Juliana Nascimento MARTINS Pontifícia Universidade Católica de Campinas

DOI:

https://doi.org/10.24220/2318-0897v24n3a3312

Palavras-chave:

Carcinoma. Síndrome do nevo basocelular. Tumores odontogênicos.

Resumo

Este estudo tem por objetivo realizar uma revisão de literatura sobre a Síndrome de Gorlin Goltz com foco em sua principal complicação odontológica, o Tumor Odontogênico Ceratocístico. A busca foi feita nas bases de dados Pubmed, Science Direct e Wiley Online Library. Buscou-se artigos clínicos e pesquisas publicados no período de 2010 a 2015 que estivessem relacionados à Síndrome de Gorlin Goltz e ao Tumor Odontogênico Ceratocístico ou que abordassem a inter-relação entre ambos. Além disso, também foram selecionados estudos os quais abrangessem a importância do cirurgião dentista no diagnóstico precoce da morbidade de base a partir de achados do referido tumor. Somente as pesquisas em língua estrangeira, preferencialmente em inglês, foram incluídas nesta revisão. Diante das alterações fisiopatológicas que a Síndrome de Gorlin Goltz causa, compreende-se a relevância do acompanhamento desses pacientes por uma equipe multiprofissional, especialmente pelo cirurgião dentista, uma vez que este é o responsável direto pelo diagnóstico e tratamento da principal morbidade associada à síndrome.

 Palavras-chave: Carcinoma. Síndrome do nevo basocelular. Tumores odontogênicos.

Downloads

Não há dados estatísticos.

Biografia do Autor

Juliana Nascimento MARTINS, Pontifícia Universidade Católica de Campinas

1 Pontifícia Universidade Católica de Campinas, Hospital e Maternidade Celso Pierro, Programa de Residência Multiprofissional em
Saúde-Urgência e Trauma. Av. John BoydDunlop, s/n., Jardim Ipaussurama, 13060-904, Campinas, SP, Brasil. E-mail:
<juliananm.ruminigh@hotmail.com>.

Referências

Rodríguez RG, Cossìo PI, Parejo PR, Carranza ET, García

AGP, Castro DS. Síndrome de Gorlin-Goltz: manejo

del carcinoma basocelular facial. Rev Esp Cir Oral

Maxilofac. 2013; 35(1):23-30.

Casaroto AR, Loures DCNR, Moreschi E, Veltrini VC,

Trento CL, Gottardo VD, et al. Early diagnosis of Gorlin-

Goltz syndrome: case report. Head Face Med. 2011;

:2.

Chandran S, Marudhamuthu k, Riaz R, Balasubramaniam

S. Odontogenic keratocysts in Gorlin-Goltz

Syndrome: A case report. J Int Oral Health. 2015;

(Suppl. 1):76-9

Mazzuoccolo LD, Martinez MF, Muchnik C, Azurmendi

P, Stengel F. Síndrome de carcinoma basocelular

nevoide con agenesia de cuerpo calloso, mutación

en PTCH1 y ausencia de carcinoma basocelular. Rev

Med (Buenos Aires). 2014; 74(4):307-10.

Sasaki R, Miyashita T, Matsumoto N, Fujii K, Saito K,

Ando T. Multiple keratocystic odontogenic tumors

associated with nevoid basal cell carcinoma syndrome

having distinct PTCH1 mutations: A case report. Oral

Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;

(2):41-6.

Borgonovo AE, Lascia SD, Grossi G, Maiorana C. Twostage

treatment protocol of keratocystic odontogenic

tumour in young patients with Gorlin-Goltz

syndrome: Marsupialization and later enucleation

with peripheral ostectomy. A 5-year-follow-up

experience. Int J Pediatr Otolaryng. 2011;

(12):1565-71.

Gupta SR, Jaetli V, Mohanty S, Shama R, Gupta A.

Nevoid basal cell carcinoma syndrome in Indian

patients: A clinical and radiological study of 6 cases

and review of literature. Oral Surg Oral Med Oral

Pathol Oral Radiol. 2012; 113(1):99-110.

Yamamoto T, Ichioka H, Yamamoto K, Kanamura N,

Sumitomo S, Shikimori M, et al. Nevoid basal cell

carcinoma syndrome: Clinical features and

implications of development of basal cell carcinoma

in skin and keratocystic odontogenic tumor in jaw

and their gene expressions. Asian J Oral Maxillofac

Surg. 2011; 23(3):105-12.

Jeyaraj P, Naresh N, Srinivas V. Case report on multiple

keratocystic odontogenic tumors of jaws: Comparison

of a non-syndromic case versus a case of Gorlin Goltz

Syndrome. J Oral Maxillofac Surg Med Pathol. 2014;

(4):569-575.

Mojsa I, Stypulkowska J, Kaczmarzyk T, Okon K, Zaleska

M. Treatment of a patient with large keratocystic

odontogenic tumour in the mandible: Case report

with literature review. Oral Surg. 2012; 5(1):1-6.

Kalia V, Kaushal N, Kalra G. The syndromic multiple

odontogenic keratocyst in siblings: A familial study.

Ann Maxillofac Surg. 2011; 1(1):77-82.

Kargahi N, Kalantari M. non-syndromic multiple

odontogenic keratocyst: A case Report. J Dent (Shiraz).

; 14(3):151-4.

Almeida Júnior P, Cardoso LC, Garcia Júnior IR, Magro

Filho O, Luvizuto ER, Felipini RC. Conservative

approach to the treatment of keratocystic odontogenic

tumor. J Dent Child. 2010; 77(3):135-9.

Santos JN, Carneiro Junior B, Alves Malaquias PDTI,

Henriques, ACG, Cury PR, Rebello IMCR. Keratocystic

odontogenic tumour arising as a periapical lesion.

Int Endod J. 2014; 47(8):802-9.

Siles MS, Alonso FC, Jornet PL, Sanchez NS.

Keratocystic odontogenic tumor: A case report and

review of the literature. N Y State Dent J.2013;

(2):44-7.

Shimada Y, Morita K, Kabasawa Y, Taguchi T, Omura

k. Clinical manifestations and treatment for

keratocystic odontogenic tumors associated with

nevoid basal cell carcinoma syndrome: A study in 25

Japanese patients. J Oral Pathol Med. 2013;

(3):275-80.

Leonardi R, Matthews JB, Caltabiano R, Greco M,

Lombardo C, Loreto C, et al. MMP-13 expression in

keratocyst odontogenic tumour associated with

NBCCS and sporadic keratocysts. Oral Dis. 2010;

(8):795-800.

Kadlub N, Gatibelza ME, El Houmami N, Coulomb-

Lhermine A, Descroix V, Ruhin-Poncet B, et al. Tumeurs

ke´ratokystiques odontoge‘nes de l’enfant et

syndrome de Gorlin. Comment expliquer les re´cidives

et l’agressivite´ des le´sions? Rev Stomatol Chir

Maxillofac Chir Orale. 2012; 113(3):148-54.

Pierro VS. Clinical and oral findings in an Afro-

Brazilian family with Gorlin-Goltz syndrome: Case

series and literature review. Spec Care Dentist. 2015;

(1):43-50.

Sung-Il Y, Young-In P, So-Young C, Jin-Wook K, Chin-

Soo K. A retrospective study of 220 cases of

keratocystic odontogenic tumor (KCOT) in 181

patients. Asian J Oral Maxillofac Surg. 2011;

(3):117-21.

Titinchi F, Nortje CJ. Keratocystic odontogenic tumor:

A recurrence analysis of clinical and radiographic

parameters. Oral Surg Oral Med O, 2012; 114(1):136-

McDonald DS, Li TK, Goto TK. A consecutive case series

of nevoid basal cell carcinoma syndrome affecting

the Hong Kong Chinese. Oral Surg Oral Med Oral

Pathol Oral Radiol. 2015; 120(3):408-15.

Malcic AI, Breen L, Josic D, Krmec SJ, Dzombeta T,

Matijevic J, et al. Proteomics profiling of keratocystic

odontogenic tumours reveals AIDA as novel

biomarker candidate. J Oral Pathol Med. 2015;

(5):367-77.

Therkildsen NM, Andersen K, Blomlöf J. Diagnostic

sensitivity and specificity in a retrospective clinical,

radiographic and histopathological study of 166

cystic jawlesions. Oral Surg.2014; 7(1):33-8.

Kulkarni GH, Khaji SI, Metkari S, Harish S, Kulkarni

HS, Kulkarni R. Multiple keratocysts of the mandible

in association with Gorlin-Goltz syndrome: A rare case

report. Contemp Clin Dent. 2014; 5(3):419-21.

Chander M, Mishra M, Gaur A, Fatima T, Mondal S,

Dhar S. Gorlin Goltz syndrome: A case report. Int J Sci

Res. 2015; 2(1):20-24.

Downloads

Publicado

2016-10-05

Como Citar

MARTINS, J. N. (2016). Síndrome de Gorlin Goltz e suas implicações odontológicas. Revista De Ciências Médicas, 24(3), 113–119. https://doi.org/10.24220/2318-0897v24n3a3312