Tratamento da mucosite oral com laser de baixa potência: revisão sistemática de literatura
DOI:
https://doi.org/10.24220/2318-0897v24n2a2959Palavras-chave:
Estomatite. Mucosite. Quimioterapia. Radioterapia. Terapia a laser de baixa intensidade.Resumo
Verificar qual o melhor protocolo de aplicação da laserterapia de baixa potência para prevenção e tratamento da mucosite oral químio e rádio induzida. Revisão sistemática de literatura sobre laserterapia na prevenção e tratamento da mucosite oral rádio e químio induzida. Foram utilizadas as indexações “mucositis”, “lowpower laser therapy”, na busca de estudos clínicos randomizados dos últimos 10 anos nas bases de dados de referência: PubMed, LILACS e Cochrane Library. A pesquisa resultou em 16 estudos clínicos randomizados sobre laserterapia de baixa potência, sendo consenso a aplicação 5 vezes por semana, com densidade de energia variada entre 1,3 e 6,0 J/cm². O presente estudo identificou que a laserterapia reduz o tempo de cicatrização e os graus de mucosite oral, apesar de ainda serem necessários mais estudos para definir o protocolo de atuação.
Palavras-chave: Estomatite. Mucosite. Quimioterapia. Radioterapia. Terapia a laser de baixa intensidade.
Downloads
Referências
Bensadoun RJ, Nair RG. Low-level laser therapy in the
prevention and treatment of cancer therapy-induced
mucositis: State of the art based on literature review
and meta-analysis. Curr Opin Oncol. 2012; 24(4):363-
Carvalho PAG, Jaguar GC, Pellizzon AC, Prado JD,
Lopes RN, Alves FA. Evaluation of low-level laser
therapy in the prevention and treatment of radiationinduced
mucositis: A double-blind randomized study
in head and neck cancer patients. Oral Oncol. 2011;
(12):1176-81.
Mañas A, Cerezo L, de la Torre A, García M, Alburquerque
H, Ludeña B, et al. Epidemiology and
prevalence of oropharyngeal candidiasis in Spanish
patients with head and neck tumors undergoing
radiotherapy treatment alone or in combination with
chemotherapy. Clin Transl Oncol. 2012; 14(10):740-
Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG,
Vadhiraja BM. Low level helium neon laser therapy
for chemoradiotherapy induced oral mucositis in oral
câncer patients: A randomized controlled trial. Oral
Oncol. 2012; 48(9):893-7.
Silva GB, Sacono NT, Othon-Leite AF, Mendonça EF,
Arantes AM, Bariani C, et al. Effect of low-level laser
therapy on inflammatory mediator release during
chemotherapy-induced oral mucositis: A randomized
preliminary study. Lasers Med Sci. 2015; 30(1):117-
Khouri VY, Stracieri AB, Rodrigues MC, Moraes DA,
Pieroni F, Simões BP, et al. Use of therapeutic laser for
prevention and treatment of oral mucositis. Braz Dent
J. 2009; 20(3):215-20.
Gouvêa de Lima A, Villar RC, de Castro Junior G, Antequera
R, Gil E, Rosalmeida MC, et al. Oral mucositis
prevention by low-level laser therapy in head-andneck
cancer patients undergoing concurrent
chemoradiotherapy: A phase III randomized study.
Int J Radiat Oncol Biol Phys. 2012; 82(1):270-5.
Arun Maiya G, Sagar MS, Fernandes D. Effect of low
level Helium-Neon (He-Ne) laser therapy in the
prevention & treatment of radiation induced mucositis
in head & neck cancer patients. Indian J Med Res.
; 124(4):399-402.
Kuhn A, Porto FA, Miraglia P, Brunetto AL. Low-level
infrared laser therapy in chemotherapy-induced oral
mucositis: A randomized placebo-controlled trial in
children. J Pediatric Hematol Oncol. 2009; 31(1):33-7.
Arora H, Pai KM, Maiya A, Vidyasagar MS, Rajeev A.
Efficacy of He-Ne Laser in the prevention and treatment
of radiotherapy-induced oral mucositis in oral cancer
patients. Oral Surg Oral Med Oral Pathol Oral Radiol
Endod. 2008; 105(2):180-6.
Fukuda TY, Malfatti CA. Análise da dose do laser de
baixa potência em equipamentos nacionais. Rev Bras
Fisioter. 2008; 12(1):70-4.
Schubert MM, Eduardo FP, Guthrie KA, Franquin JC,
Bensadoun RJ, Migliorati CA. A phase III randomized
double-blind placebo-controlled clinical trial to
determine the efficacy of low level laser therapy for
the prevention of oral mucositis in patients
undergoing hematopoietic cell transplantation.
Support Care Cancer. 2007; 15(10):1145-54.
López-Castaño F, Oñate-Sánchez RE, Roldán-Chicano
R, Cabrerizo-Merino MC. Measurement of secondary
mucositis to oncohematologic treatment by means
of different scale. Rev Med Oral Patol Oral Cir Bucal.
; 10(5):412-21.
Cruz LB, Ribeiro AS, Rech A, Rosa LG, Castro Jr CG,
Brunetto AL. Influence of low-energy laser in the
prevention of oral mucositis in children with câncer
receiving chemotherapy. Pediatr Blood Cancer. 2007;
(4):435-40.
Arbabi-Kalati F, Arbabi-Kalati F, Moridi T. Evaluation
of the effect of low level laser on prevention of
chemotherapy-induced mucositis. Acta Med Iran.
; 51(3):157-62.
Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe
DM, et al. MASCC/ISOO clinical practice guidelines
for the management of mucositis secondary to cancer
therapy. Cancer. 2014; 120(10):1453-61.
Oliveira Lopes C, Mas JRI, Zângaro RA. Prevenção da
xerostomia e da mucosite oral induzidas por
radioterapia com uso do laser de baixa potência.
RadiolBras. 2006; 39(2):131-6.
Antunes HS, Herchenhorn D, Small I, Araujo C, Cabral
E, Rampini MP, et al. Cost-effectiveness of Low-Level
Laser Therapy (LLLT) in head and neck cancer patients
submitted to concurrent chemoradiation. In:
International Symposium on Supportive Care in
Cancer; 2013, Berlin. Heidelberg; Springer; 2013. v.
Antunes HS, de Azevedo AM, da Silva Bouzas LF, Adão
CA, Pinheiro CT, Mayhe R, et al. Low-power laser in
the prevention of induced oral mucositis in bone
marrow transplantation patients: A randomized trial.
Blood. 2007; 109(5):2250-5.
Hodgson BD, Margolis DM, Salzman DE, Eastwood
D, Tarima S, Williams LD, et al. Amelioration of oral
mucositis pain by NASA near-infrared light-emitting
diodes in bone marrow transplant patients. Support
Care Cancer. 2012; 20(7):1405-15.
Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG,
Nigudgi S. Effect of low-level laser therapy on patient
reported measures of oral mucositis and quality of
life in head and neck cancer patients receiving
chemoradiotherapy: A randomized controlled trial.
Support Care Cancer. 2013; 21(5):1421-8.
Chor A, Torres SR, Maiolino A, Nucci M. Low-power
laser to prevent oral mucositis in autologous
hematopoietic stem cell transplantation. Eur J
Haematol. 2010; 84(2):178-9.
Sheibani KM, Mafi AR, Moghaddam S, Taslimi F,
Amiran A, Ameri A. Efficacy of benzydamine oral rinse
in prevention and management of radiation-induced
oral mucositis: A double-blind placebo-controlled
randomized clinical trial. Asia Pac J Clin Oncol. 2015;
(1):22-7.
Silva GB, Mendonça EF, Bariani C, Antunes HS, Silva
MA. The prevention of induced oral mucositis with
low-level laser therapy in bone marrow transplantation
patients: A randomized clinical trial.
Photomed Laser Surg. 2014; 29(1):27-31.
Bensadoun RJ, Franquin JC, Ciais G, Darcourt V,
Schubert MM, Viot M, et al. Low-energy He/Ne laser
in the prevention of radiation-induced mucositis: A
multicenter phase III randomised study in patients
with head and neck cancer. Support Care Cancer.
; 7(4):244-52.
