Ostoclerose
Palavras-chave:
otosclerose, surdez, fluoreto de sódio, calcitoninaResumo
A otospongiose é uma displasia óssea encontrada apenas no osso temporal humano e consiste em áreas de reabsorção únicas ou múltiplas seguidas de cicatrização com neoformação óssea. O resultado clínico da doença é a surdez condutiva quando da fixação do estribo na janela oval ou a surdez neurossensorial quando atinge o endósteo da cóclea. Atualmente a conduta clínica da otospongiose se restringe ao uso do fluoreto de sódio (20mg) associado ao lactato de cálcio, que podem amenizar a doença. Temos, neste momento, as seguintes propostas de tratamento clínico: inibidores de citocina, calcitonina de salmão e bisfosfonatos. Nesta breve revisão é evidenciada a etiopatogenia da otospongiose e a expectativa de novas condutas terapêuticas.
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Referências
Bento RF. Tratado de otologia. São Paulo: Fapesp; 1998.
Ralph FW, Harlan RM, Trevor JM. Pediatric Otolaryngol: principies and practice pathways. ORL [Internet]. 2000; 61-2 [cited 2004 Oct.]. Disponible from: http://content.com/produkteDB/journals
Svatko LG. Pathogenetic aspects of otosclerosis. Vestn Otorinolaringol. 1995; (3):24-7.
Shin YJ, Calvas P, Deguine O, Charlet JP, Cognard C, Fraysse B. Correlations between computed tomography findings and family history in otosclerotic patients. Otol Neurotol. 2001; 22(4):461-4.
Chale RA, McKenna M. Pathophysiology of otosclerosis. Otol Neurotol. 2001; 22(2):249-57.
Niedermeyer HP, Arnold W. Etiopathogenesis of otosclerosis. ORL J Otorhinolaryngol Relat. Spec. 2002; 64(2):114-9.
Sanchez-Alcon MD, Perez Garrigues H, Faus J, Munoz A, Morera C. Deafness in patients with osteogenesis imperfecta. An Otorrinolaringol Ibero Am. 1993; 20(4):403-14.
Ziyeh S, Berger R, Reisner K. MRl-visible pericochlear lesions in osteogenesis imperfecta type 1. Eur Radiol. 2000; 10(10):1675-7
Sismanis A, Hughes GB, Abedi E. Coexisting otosclerosis and Meniere's disease: a diagnostic and therapeutic dilemma. Laryngoscope. 1986; 96(1):9-13.
O. Di Nardo A, Parlapiano C, Di Prima M, Minni A. Otosclerosis. lmmunoendocrine and infective aspects. Eur Sei Med Farmacol. 1993; 1 5(5-6):213-8.
Arnold W, Niedermeyer HP, Altermatt HJ, Neubert WJ. Pathogenesis of otosclerosis. "State of the art". HNO. 1996; 44(3):121-9.
Yoo TJ. Etiopathogenesis of otosclerosis: a hypothesis. Ann Otol Rhinol Laryngol. 1984; 93(1 Pt 1):28-33.
Yoo TJ, Shea JJ Jr, Floyd RA. Enchondral cartilage rests collagen-induced autoimmunity: a possible pathogenetic mechanism of otosclerosis. Am J Otolaryngol. 1987; 8(5):317-24
Lopez-Gonzalez MA, Delgado F. Oral vaccine in otosclerosis. Med Hypotheses. 2000; 54(2):216-20.
Ogawa K, lnoue Y, Shinden S, Kumanomidou H, Ide R, Kanzaki J. Pathogenesis mechanism in ear fullness in otosclerosis. Nippon Jibiinkoka Gakkai Kaiho. 2001; 104(3):187-91.
Causse JR, Uriel J, Berges J, Shambaugh GE Jr, Bretlau P, Causse JB. The enzymatic mechanism of the otospongiotic disease and NaF action on the enzymatic balance. Am J Otol. 1982; 3(4):297-314
Harris JP, Keithley EM. lnner ear inflammation and round window otosclerosis. Am J Otol. 1993; 14(2):109-12.
Shin YJ, Deguine O, Cognard C, Sevely A, Manelf C, Fraysse B. Reliability of CT scan in the diagnosis of conductive hearing loss with normal tympanic membrane. Ver Laryngol Otol Rhinol (Bord) 2001; 23:431-38.
Valvassori GE. lmaging of the otosclerosis. Otolaryngol Clin North America. 1993; 26(3):359-71.
Berrettini S, et ai. Single Photon Emission Computed Tomography in Otosclerosis: Diagnostic accuracy and correlation with age, sex, and sensorineural involvement. Otol Neurotol. 2002; 23:431-38.
Swartz JD, et ai. Fenestral and cochlear otosclerosis: Computed Tomographic evaluation. Am J Otol. 1985; 6(6):476-81.
Shin YJ, Fraysse B, Deguine O, Cognard C, Charlet JP, Sevely A. Sensorineural hearing loss and otosclerosis: a clinicai and radiologic survey of 437 cases. Acta Otolaryngol. 2001; 121(2):200-4.
Sellari-Franceschini S, Ravecca F, De Vito A, Berretini S. Progressive sensorineural hearing loss in cochlear ostosclerosis. Acta Otorhinolaryngol ltal. 1998; 18(4 Suppl 59):59-65.
Derks W, De Groot JA, Raymakers JA, Veldman JE. Fluoride therapy for cochlear otosclerosis? an audiometric and computerized tomography evaluation. Acta Otolaryngol. 2001; 121(2):174-7.
Lacosta JL, Infante JC, Sanchez Galan L. Calcitonin and otosclerosis: a preliminary clinicai note. Acta Otorrinolaringol Esp. 1997; 48(7):561-4
Brookler KH, Tanyeri H. Etidronate for the neurotologic symptoms of otosclerosis: preliminary study Ear Nose Thoat J. 1997; 76(6):379-81.
Szekanecz Z, Szekanecz E, Morvai K, Racs T, Szegedi G, Szikilai 1. Current aspects of the pathogenesis and clinicai characteristics of otosclerosis: possibilities of drug therapy. Orv Hetil. 1999; 140(44):2435-40
