Linfoma Malt de conjuntiva: o diagnóstico ao alcance do primeiro olhar
Palavras-chave:
conjuntiva, linfoma do tecido linfóide associado a mucosa, tecido linfóideResumo
O linfoma de zona marginal extranodal do tecido linfóide associado à mucosa (ou Linfoma MALT) é uma neoplasia linfocitária que surge a partir de qualquer tecido linfóide organizado. Esse linfoma pode acometer diversos órgãos, sendo raro na conjuntiva. Lesões expansivas conjuntivais podem ter vários diagnósticos diferenciais clínicos e histopatológicos, nem todos de histogênese tumoral. Este relato tem como objetivo descrever um caso incomum de tumor na conjuntiva, pouco sintomático, de fácil visibilização e de evolução clínica indolente. São também descritos dados atuais sobre o assunto, com ênfase no comportamento biológico dessas lesões.
Downloads
Referências
Jaffe ES, Harris NL, Stein H, Vardiman JW Pathology & Genetics of tumours of Haematopoietic and Lymphoid tissue. WHO Classification of tumours. Lyon: IARC Press; 2001.
Sarraf D, Jain A, Dubovv S, Kreiger A, Fong D, Paschal J. Mucosa-associated lymphoid tissue lymphoma with intraocular involvement. Retina. 2005; 25(1):94-8.
Lee JL, Kim MK, Lee KH, Hyun MS, Chung Hs, Kim DS, et ai. Extranodal marginal zone B- cell lymphomas of mucosa-associated lymphoid tissue: type of the orbit and ocular adnexa. Ann hematol. 2005; 84(1):13-8.
Tonami H, Matoba M, Yokota H, Higashi K, Yamamoto 1, Sugai S. Mucosa-associated lymphoid tissue lymphoma in Sjõgren's syndrome: initial and follow-up imaging feactures. Am J Roentgenol. 2002; 179: 485-9.
Yeung L, Tsao YP, Chen PY, Kuo TT, Lin KK, Lai LJ. Combination of adult inclusion conjunctivitis and mucosa-associated lymphoid tissue (MALT) lymphoma in a young adult. Cornea. 2004; 23(1):71-5.
Mannami T, Yoshino AK, Takase S, Kondo E, Ohara N, Nakagawa H, et ai. Clinicai, histopathological and immunogenetic analysis of ocular adnexal lymphoproliferative disorders: characterization of malt lymphoma and reactive lymphoid hyperplasia. Mod Pathol. 2001; 14(7):641-9.
Nechesniuk SI, Probatova NA, Grishina EE, Kovrigina Am, Tupitsvn NN, Sholokhova EN. Lymphoproliferative diseases of the orbit and appendages of the eye. Arkh Patol. 2001; 63(1):27-32.
Knop N, Knop E. Conjunctiva- associated lymphoid tissue in the human eye. lnvest Ophthalmol Vis Sei. 2000; 41(6):1270-9.
Hingorani M, Metz D, Lightman SL. Characterisation of the normal conjuctival leukocyte population. Exp Eye Res. 1997; 64(6):905-12.
Wotherspoon AC, Hardman-Lea S, lsaacson PG. Mucosa-associated lymphoid tissue (MALT) in the human conjunctiva. J Pathol. 1994; 174(1):33-7.
Yamashita T, Mattos A C, Ferreira MCF, Alvarenga M. Helicobacter pylori e linfoma gástrico de células B da zona Marginal do tipo MALT. Rev Ciênc Méd. Campinas, 2006; 15(5):449-54.
Raderer M, Vorbeck F, Formanek M, Osterreicher C, Valencak J, Penz M, et ai. lmportance of extensive staging in patients with mucosa- associated lymphoid tissue (MALT) - type lymphoma. Br J Cancer. 2000; 83(4):454-7.
Calvo R, Ribera JM, Vaquero M, Garcia O, Moreno 1, Feliu E. Low- grade malt-type primary b- cell lymphoma of the conjuctiva. Leuk Lymphoma. 1997; 28(1-2): 203-7.
Kurz-Levin MM, Flury R, Bernauer W. Diagnosis of MALT lymphoma by conjuctival biopsy: a case report. Graefes Arch Clin Exp Ophthalmol. 1997; 235(9) 606-9.
Minasian MC, Sharma A, Richman PI, Olver JM. Conjunctival MALT lymphoma: an anusual case of red eye. Postgrad Med J. 1999; 75(885):423-4.
Primary lymphoma of the conjunctiva -a rare manifestation of indolent non-Hodgkin's lymphoma. Ann Hematol. 2001; 80(5):311-3.
Cahill M, Baenes C, Moriarty P, Daly P, kennedy S. Ocular adnexal lymphoma- comparison of MALT lymphoma with other histological types. Br J Ophthalmol. 1999; 83(6):742-7.
Le QT, Eulau SM, George TI, Hildebrand R, Warnke RA, Donaldson SS, et ai. Primary radiotherapy for localized orbital MALT lymphoma. lnt J Radat Oncol Biol Phys. 2002; 52(3):657-63
Uno T, lsobe K, Shikama N, Nishikawa A, Oguchi M, Ueno N, et ai. Radiotherapy for extranodal marginal zone 8- cell lymphoma of mucosa- associated lymphoid tissue originating in the ocular adnexa: a multiinstitutional retrospective review of 50 patients. Cancer. 2003; 98(4):865-71.
Tanimoto K, Kaneko A, Suzuki S, Sekiguchi N, Kim S, Kagami Y, et ai. Long term follow-up results of no initial therapy for ocular adnexal MALT lymphoma. Ann Oncol. 2006; 17(1):135-40.