Efeitos farmacológicos dos fungos Agaricales: uma revisão de evidência

Autores

  • Maria Rita Carvalho Garbi Novaes
  • Luiz Carlos Garcez Novaes
  • Vanessa Cunha Taveira

Palavras-chave:

Agaricus, Neoplasias, Suplementação nutricional

Resumo

Quantidades suplementares de cogumelos comestíveis podem ser usadas não somente como simples implemento de substrato nitrogenado, mas também como auxiliares no tratamento do câncer, devido a seus efeitos farmacológicos, especialmente os dos fungos da ordem Agaricales. O objetivo deste trabalho foi avaliar os efeitos farmacológicos de fungos Agaricales em pacientes com câncer, a partir de uma revisão sistemática e crítica da literatura, usando as seguintes bases de dados: Medline, Database, Nacional Center of Biotechnology lnformation, Lilacs e Cochrane. O uso de cogumelos comestíveis pode consistir em uma nova possibilidade terapêutica para o tratamento do câncer, embora sejam necessários estudos clínicos controlados e triagens randomizadas adicionais para estabelecer os critérios de uso em pacientes com câncer.

Downloads

Não há dados estatísticos.

Referências

Sulivan R, Smith JE, Rowan NJ. Medicinal mushrooms and cancer therapy: translating a traditional practice to Western medicine. Perspec Biol Med. 2006; 49(2):159.

Jong SC, Birmingham JM, Pai SH. lmmuno­ modulatory substances of fungai origin. J lmmunol lmmunopharmacal. 1991; 11(3):788-881.

Mizuno T, Zhuang C. Maitake grifo/a frondosa, pharmacalogical effects. Food Rev lnt. 1995; 111:135- 49.

Novaes MRG, Garcez LCG, Melo A, Recava V. Effects of agaricus silvaticus mushrooms on hematological and immunological systems in rats with ascitic Walker 256 tumor. Rev Bras Nutr Clin. 2007; 22(2):116-20

lto H, Shimura K. Studies on the antitumor activity of traditional Chinese medicines. (11). The antitumor mechanism of traditional Chinese medicines. Gan to Kagaku Ryoho. 1986; 12(11):2149-54.

Parslew R, Jones KT, Rhotdes JM, Sharpe GR. The antiproliferative effect of lectin from edible mushroom (Agaricus bisporus) on human keratinocytes: preliminary studies on its use in psoriasis. Br J Dermatol. 1999; 140(1):56-60.

Yu LG, Fernig DG, White MRH, Spiller DG, Appleton P, Evans RC, et ai. Edible mushroom (agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence­ dependent nuclear protein import. J Biol Chem. 1999; 274(8):4890-9.

Kuo YC, Yu LH, Chen CC, Lin YS, Chuang KN, Tsai WJ. Cell cycle progression and cytokine gene expression of human peripheral blood mononuclear cells modulated by Agaricus blazei. J Lab Clin Med. 2002; 140(3):176-87.

lto H, lto H, Amano H, Nada H. lnhibitory action of a (1-6)-beta-glucan-protein camplex (F I11-2-b) isolated from Agaricus blazei Murill ("himematsutake") on Metha-A fibrosarcoma- bearing mice and its antitumor mechanism. Jpn J Pharmacal. 1994; 66(2):265-71.

O. Grube BJ, Eng ET, Kao YC, Kwon A, Chen S. White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. J Nutr. 2001; 131(12):328-42.

Ruwei W, Yiyuan X, Peijun J, Xingli W, Holliday JC. lmmune fx clinicai triai of immune assist (a specific mixture of 6 medicinal mushroom extracts). Recavery Biostructural Medicine-Biomedica; 2001.

Hui TX, Guo LZ, Jing W, lto H, Shimura K, Zhi WJ. Clinicai observation on treatment of acute non Lymphocytic leukemia with Agaricus blazei Murrill. Nutr Notebook. 1988; 886.

Fortes RC, Recava VC, Melo AL, Novaes MRCG. Quality of life of patients with calorectal cancer on dietary supplementation with Agaricus Sylvaticus fungus: after six months of segment: randomized and placebo-cantrolled clinicai triai. Rev Bras Coloproct. 2007; 27(2):130-8.

Ebina T, Fujimiya Y. Antimumor effect of a peptide­ glucan extracted of Agaricus blazei in a double grafted tumor system in mice. Biotherapy. 1998; 11(4):259- 65.

Takei T, Yoshida M, Ohnishi-Kameyama M, Kobori M. Ergosterol peroxide, an apoptosis inducing camponent isolated from Sarcodon aspratus (Berk). Biotechnol Biochem. 2005; 69(1):212-5.

Wang H, Ng TB. lsolation of a novel N­ acetyl gIucosa mi ne-specific lectin from fresh sclerotinia of the edible mushroom Pleurotus tuber­ regium. Protein Expr Purif. 2003; 29(2):156-60.

Jenneman R, Bauer BL, Bertalanffy H, Selmer T, Wiegandt H. Basidiolipids from Agaricus are novel immune adjuvants. lmmunobiology. 1999; 200(2):277-89.

Fujimya Y, Suzuki Y, Katakura R, Ebina T. Tumor-specific cytocidal and imunopotentiating effects of relatively low molecular weight products derived from basidiomycete, Agaricus blazei Murill. Anticancer Res. 1999; 19(1A):113-8.

Zhao C, Sun H, Tong X, Oi Y. An antitumor lectin from the edible mushroom Agrocybe aegerita. Biochem J. 2003; 374(Pt2):321-7.

Takeshi T, Yoshiyuki K, Hiromichi O. lsolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr. 2001; 131:1409-13.

Lin SB, Li C H, Lee SS, Kan LS. Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2- phase cell cycle arrest. Life Sei. 2003; 72:2381-90.

Sorimachi K, Akimoto K, lkehara Y, lnafuku K, Okubo A, Yamazaki S. Secretion of TNF-alfa, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fraction in vitro. Cell Struct Funct. 2001; 26(2):103-8.

Hozová B, Kuniak L, Kelemenová B. Applications of â­ D-glucans isolated from mushrooms Pleurotus ostreatus (Pleuran) and Lentinus edodes (Lentinan) for increasing the bioactivity of yogurts. Czech J Food Sei. 2004; 22(6):204-14.

Rice PJ, Lockhart BE, Barker LA, Adams EL, Ensley HE, Williams DL. Pharmacokinetics of fungai (1-3)- -D­ glucans following intravenous administration in rats. lnt lmmunopharmacol. 2004; 4(9):1209-15.

Fortes RC, Taveira VC, Novaes MRCG. Papel imunomodulador das -D-glucanas na terapia adjuvante do câncer. Rev Bras Nutr Clin. 2006; 21(2):163-8.

Hong F, Yan J, Baran JT, Allendorf DJ, Hansen LD, Ostroff DF, et ai. Mechanism by which orally administered -1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J lmmunol. 2004; 173:797-803.

See D, Mason S, Roshan R. lncreased tumor necrosis factor alfa (TNF-alfa) and natural Killer cell (NK) function using an integrative approach in late stage cancers. lmmunol lnvest. 2002; 31(2):137-53

Harada T, Masuda S, Arii M, Adashi Y, Nakajima M, Yadomae T, et ai. Soy isoflavone aglycone modulates a hematopoietic response in combination with soluble â-glucan: SCG. Biol Pharm Buli. 2005; 28(12):2342-5

Jing W, Min MX, Zheng CR, Zhi WJ, lto H, Shimura K. Observation on treatment effect of Agaricus blazei Murill against alimentary tract tumor. Nutr Notebook. 1988; 866-82.

Shimizu S, Kitada H, Yokota H, Yamakawa J, Murayama T, Sugiyama K, et ai. Activation of the alternative complement pathway by Agaricus blazei Murril. Phytomedicine. 2002; 9(6):536-45.

Mizuno T. Pharmacological and gastronomic effects of fungi and its applications. Chem Times. 1989; 1:12- 21.

Nanba H. Activity of maitake D-fraction to inhibit carcinogenesis and metastasis. Ann NY Acad Sei. 1995; 768:243-5.

Novaes MRCG, Lima LAM, Novaes LCG. Metabolic and hematological effects of dietary supplementation with arginine on rats bearing ascitic Walker 256 tumor. Ann Nutr Metab. 2004; 48(6):404-8.

Novaes MRCG, Lima LAM, Ribeiro JEG, Magalhães AV, Sousa MV, Morhy L. Pharmacological effects of arginine supplementation in rats with Walker 256 solid tumor. Arch Latinoam Nutr. 2000; 50(3):230-6.

Novaes MRCG, Lima LAM, Souza MV. Effects of the diet suplement using arginine 6% into experimental tumor. J Metab Nutr. 1998; 5:40-4.

Novaes MRCG, Lima LAM. Effect of dietetic supplementation with L-arginine in cancer patients. A review of the literature. Arch Latinoam Nutr. 1999; 49(4):301-6.

Novaes MRCG, Pantaleão C. Pharmacological effects of nutritional supplementation of arginine in gastrointestinal cancer patients. Braz J Clin Nutr. 2004; 19(1):26-31

lto H, Shimura K, ltoh H, Kawade M. Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (lwade strain 1O1) Himematsutake and its mechanisms in tumor-bearing mice. Anticancer Res. 1997; 17(1A):277-84

Mizuno T, Hagiwara T, Nakamura T, lto H, Shimura K, Sumiya T, et ai. Antitumor activity and some properties of water-soluble polysaccharides from "Himematsutake", fruiting body of Agaricus blazei Murill. Jpn Biai Abst. 1994; 98(7):14

Shimura K, lto H, Hibasami H. Screening of host­ mediated antitumor polysaccharides by crossed imunoelectrophoresis using fresh human serum. J J Pharmacol. 1983; 33(2):403-8.

Manzi P, Marconi S, Aguzzi A, Pizzoferrato L. Commercial mushrooms: nutritional quality and effect of cooking. Food Chem. 2001; 84:201-6.

Downloads

Publicado

2007-04-30

Como Citar

Novaes, M. R. C. G., Novaes, L. C. G., & Taveira, V. C. (2007). Efeitos farmacológicos dos fungos Agaricales: uma revisão de evidência. Revista De Ciências Médicas, 16(2). Recuperado de https://seer.sis.puc-campinas.edu.br/cienciasmedicas/article/view/1065

Edição

Seção

Revisão