Efeitos farmacológicos dos fungos Agaricales: uma revisão de evidência
Palavras-chave:
Agaricus, Neoplasias, Suplementação nutricionalResumo
Quantidades suplementares de cogumelos comestíveis podem ser usadas não somente como simples implemento de substrato nitrogenado, mas também como auxiliares no tratamento do câncer, devido a seus efeitos farmacológicos, especialmente os dos fungos da ordem Agaricales. O objetivo deste trabalho foi avaliar os efeitos farmacológicos de fungos Agaricales em pacientes com câncer, a partir de uma revisão sistemática e crítica da literatura, usando as seguintes bases de dados: Medline, Database, Nacional Center of Biotechnology lnformation, Lilacs e Cochrane. O uso de cogumelos comestíveis pode consistir em uma nova possibilidade terapêutica para o tratamento do câncer, embora sejam necessários estudos clínicos controlados e triagens randomizadas adicionais para estabelecer os critérios de uso em pacientes com câncer.
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Referências
Sulivan R, Smith JE, Rowan NJ. Medicinal mushrooms and cancer therapy: translating a traditional practice to Western medicine. Perspec Biol Med. 2006; 49(2):159.
Jong SC, Birmingham JM, Pai SH. lmmuno modulatory substances of fungai origin. J lmmunol lmmunopharmacal. 1991; 11(3):788-881.
Mizuno T, Zhuang C. Maitake grifo/a frondosa, pharmacalogical effects. Food Rev lnt. 1995; 111:135- 49.
Novaes MRG, Garcez LCG, Melo A, Recava V. Effects of agaricus silvaticus mushrooms on hematological and immunological systems in rats with ascitic Walker 256 tumor. Rev Bras Nutr Clin. 2007; 22(2):116-20
lto H, Shimura K. Studies on the antitumor activity of traditional Chinese medicines. (11). The antitumor mechanism of traditional Chinese medicines. Gan to Kagaku Ryoho. 1986; 12(11):2149-54.
Parslew R, Jones KT, Rhotdes JM, Sharpe GR. The antiproliferative effect of lectin from edible mushroom (Agaricus bisporus) on human keratinocytes: preliminary studies on its use in psoriasis. Br J Dermatol. 1999; 140(1):56-60.
Yu LG, Fernig DG, White MRH, Spiller DG, Appleton P, Evans RC, et ai. Edible mushroom (agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence dependent nuclear protein import. J Biol Chem. 1999; 274(8):4890-9.
Kuo YC, Yu LH, Chen CC, Lin YS, Chuang KN, Tsai WJ. Cell cycle progression and cytokine gene expression of human peripheral blood mononuclear cells modulated by Agaricus blazei. J Lab Clin Med. 2002; 140(3):176-87.
lto H, lto H, Amano H, Nada H. lnhibitory action of a (1-6)-beta-glucan-protein camplex (F I11-2-b) isolated from Agaricus blazei Murill ("himematsutake") on Metha-A fibrosarcoma- bearing mice and its antitumor mechanism. Jpn J Pharmacal. 1994; 66(2):265-71.
O. Grube BJ, Eng ET, Kao YC, Kwon A, Chen S. White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. J Nutr. 2001; 131(12):328-42.
Ruwei W, Yiyuan X, Peijun J, Xingli W, Holliday JC. lmmune fx clinicai triai of immune assist (a specific mixture of 6 medicinal mushroom extracts). Recavery Biostructural Medicine-Biomedica; 2001.
Hui TX, Guo LZ, Jing W, lto H, Shimura K, Zhi WJ. Clinicai observation on treatment of acute non Lymphocytic leukemia with Agaricus blazei Murrill. Nutr Notebook. 1988; 886.
Fortes RC, Recava VC, Melo AL, Novaes MRCG. Quality of life of patients with calorectal cancer on dietary supplementation with Agaricus Sylvaticus fungus: after six months of segment: randomized and placebo-cantrolled clinicai triai. Rev Bras Coloproct. 2007; 27(2):130-8.
Ebina T, Fujimiya Y. Antimumor effect of a peptide glucan extracted of Agaricus blazei in a double grafted tumor system in mice. Biotherapy. 1998; 11(4):259- 65.
Takei T, Yoshida M, Ohnishi-Kameyama M, Kobori M. Ergosterol peroxide, an apoptosis inducing camponent isolated from Sarcodon aspratus (Berk). Biotechnol Biochem. 2005; 69(1):212-5.
Wang H, Ng TB. lsolation of a novel N acetyl gIucosa mi ne-specific lectin from fresh sclerotinia of the edible mushroom Pleurotus tuber regium. Protein Expr Purif. 2003; 29(2):156-60.
Jenneman R, Bauer BL, Bertalanffy H, Selmer T, Wiegandt H. Basidiolipids from Agaricus are novel immune adjuvants. lmmunobiology. 1999; 200(2):277-89.
Fujimya Y, Suzuki Y, Katakura R, Ebina T. Tumor-specific cytocidal and imunopotentiating effects of relatively low molecular weight products derived from basidiomycete, Agaricus blazei Murill. Anticancer Res. 1999; 19(1A):113-8.
Zhao C, Sun H, Tong X, Oi Y. An antitumor lectin from the edible mushroom Agrocybe aegerita. Biochem J. 2003; 374(Pt2):321-7.
Takeshi T, Yoshiyuki K, Hiromichi O. lsolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr. 2001; 131:1409-13.
Lin SB, Li C H, Lee SS, Kan LS. Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2- phase cell cycle arrest. Life Sei. 2003; 72:2381-90.
Sorimachi K, Akimoto K, lkehara Y, lnafuku K, Okubo A, Yamazaki S. Secretion of TNF-alfa, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fraction in vitro. Cell Struct Funct. 2001; 26(2):103-8.
Hozová B, Kuniak L, Kelemenová B. Applications of â D-glucans isolated from mushrooms Pleurotus ostreatus (Pleuran) and Lentinus edodes (Lentinan) for increasing the bioactivity of yogurts. Czech J Food Sei. 2004; 22(6):204-14.
Rice PJ, Lockhart BE, Barker LA, Adams EL, Ensley HE, Williams DL. Pharmacokinetics of fungai (1-3)- -D glucans following intravenous administration in rats. lnt lmmunopharmacol. 2004; 4(9):1209-15.
Fortes RC, Taveira VC, Novaes MRCG. Papel imunomodulador das -D-glucanas na terapia adjuvante do câncer. Rev Bras Nutr Clin. 2006; 21(2):163-8.
Hong F, Yan J, Baran JT, Allendorf DJ, Hansen LD, Ostroff DF, et ai. Mechanism by which orally administered -1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J lmmunol. 2004; 173:797-803.
See D, Mason S, Roshan R. lncreased tumor necrosis factor alfa (TNF-alfa) and natural Killer cell (NK) function using an integrative approach in late stage cancers. lmmunol lnvest. 2002; 31(2):137-53
Harada T, Masuda S, Arii M, Adashi Y, Nakajima M, Yadomae T, et ai. Soy isoflavone aglycone modulates a hematopoietic response in combination with soluble â-glucan: SCG. Biol Pharm Buli. 2005; 28(12):2342-5
Jing W, Min MX, Zheng CR, Zhi WJ, lto H, Shimura K. Observation on treatment effect of Agaricus blazei Murill against alimentary tract tumor. Nutr Notebook. 1988; 866-82.
Shimizu S, Kitada H, Yokota H, Yamakawa J, Murayama T, Sugiyama K, et ai. Activation of the alternative complement pathway by Agaricus blazei Murril. Phytomedicine. 2002; 9(6):536-45.
Mizuno T. Pharmacological and gastronomic effects of fungi and its applications. Chem Times. 1989; 1:12- 21.
Nanba H. Activity of maitake D-fraction to inhibit carcinogenesis and metastasis. Ann NY Acad Sei. 1995; 768:243-5.
Novaes MRCG, Lima LAM, Novaes LCG. Metabolic and hematological effects of dietary supplementation with arginine on rats bearing ascitic Walker 256 tumor. Ann Nutr Metab. 2004; 48(6):404-8.
Novaes MRCG, Lima LAM, Ribeiro JEG, Magalhães AV, Sousa MV, Morhy L. Pharmacological effects of arginine supplementation in rats with Walker 256 solid tumor. Arch Latinoam Nutr. 2000; 50(3):230-6.
Novaes MRCG, Lima LAM, Souza MV. Effects of the diet suplement using arginine 6% into experimental tumor. J Metab Nutr. 1998; 5:40-4.
Novaes MRCG, Lima LAM. Effect of dietetic supplementation with L-arginine in cancer patients. A review of the literature. Arch Latinoam Nutr. 1999; 49(4):301-6.
Novaes MRCG, Pantaleão C. Pharmacological effects of nutritional supplementation of arginine in gastrointestinal cancer patients. Braz J Clin Nutr. 2004; 19(1):26-31
lto H, Shimura K, ltoh H, Kawade M. Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (lwade strain 1O1) Himematsutake and its mechanisms in tumor-bearing mice. Anticancer Res. 1997; 17(1A):277-84
Mizuno T, Hagiwara T, Nakamura T, lto H, Shimura K, Sumiya T, et ai. Antitumor activity and some properties of water-soluble polysaccharides from "Himematsutake", fruiting body of Agaricus blazei Murill. Jpn Biai Abst. 1994; 98(7):14
Shimura K, lto H, Hibasami H. Screening of host mediated antitumor polysaccharides by crossed imunoelectrophoresis using fresh human serum. J J Pharmacol. 1983; 33(2):403-8.
Manzi P, Marconi S, Aguzzi A, Pizzoferrato L. Commercial mushrooms: nutritional quality and effect of cooking. Food Chem. 2001; 84:201-6.